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EC number: 203-139-7 | CAS number: 103-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- THE TOXICITY AND TOXIC MANIFESTATIONS OF 2,2-BIS-(p-CHLOROPHENYL)-1,1,1-TRICHLOROETHANE (DDT) AS INFLUENCED BY CHEMICAL CHANGES IN THE MOLECULE: A Contribution to The Relation Between Chemical Constitution and Toxicological Action
- Author:
- W. F. von OETTINGEN and N. E. SHARPLESS
- Year:
- 1 946
- Bibliographic source:
- J Pharmacol Exp Ther December 1946 88:400-413
- Reference Type:
- publication
- Title:
- Journal of Pharmacology and Experimental Therapeutics
- Year:
- 1 946
- Bibliographic source:
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 88,400,1946
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : SI7700000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 88,400,1946
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The toxicity and toxic manifestations of phenetole(as influenced bt chemical changes in DDT) in mice.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Phenetole
- EC Number:
- 203-139-7
- EC Name:
- Phenetole
- Cas Number:
- 103-73-1
- Molecular formula:
- C8H10O
- IUPAC Name:
- ethoxybenzene
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Phenetole
- Molecular Formula: C8H10O
- Molecular Weight: 122.17 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Not available
- Age at study initiation:Not available
- Weight at study initiation:20-30 gm
- Fasting period before study:Not available
- Housing:individual cages
- Diet (e.g. ad libitum):Purina dog chow(ad libitum)
- Water (e.g. ad libitum):water(ad libitum)
- Acclimation period:Not available
ENVIRONMENTAL CONDITIONS
- Temperature (°C):Not available
- Humidity (%):Not available
- Air changes (per hr):Not available
- Photoperiod (hrs dark / hrs light):Not available
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle:5,10 or 25 percent solutions in olive oil
- Amount of vehicle (if gavage):Not available
- Justification for choice of vehicle:Not available
- Lot/batch no. (if required):Not available
- Purity:Not available
MAXIMUM DOSE VOLUME APPLIED:Not applicable
DOSAGE PREPARATION (if unusual):5,10 or 25 percent solutions in olive oil
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose:Not available - Doses:
- 1200,1400,1600,1800,2000 & 2200 mg/kg
- No. of animals per sex per dose:
- 1200mg/kg-10
1400mg/kg-10
1600mg/kg-10
1800mg/kg-10
2000mg/kg-10
2200mg/kg-10 - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing:no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs-incidence of tremors,convulsions & fatalities noted - Statistics:
- Not availble
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 percent mortality observed
- Mortality:
- 50 percent mortality observed at 2200 mg/kg,whereas 80 percent mortality was seen at dose 2000 mg/kg and 10 percent mortality was seen at 1600 & 1800 mg/kg respectively.
- Clinical signs:
- other: Shortly after the administration the animals became depressed and with larger doses they passed into deep necrosis in 2-3 hrs and majority of animals died in a comatose condtion within 1-2 days.
- Gross pathology:
- Not available
- Other findings:
- Not available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of phenetole in mouse was found to be 2200 mg/kg of body weight as 50 percent mortality was observed at this dose.
- Executive summary:
In the study the acute oral toxicity of test compound was determined in white mice by orally administering the test compound in olive oil at doses 1200, 1400,1600,1800,2000 & 2200 mg/kg and observed for clinical signs and mortality for 1 week. The acute oral median lethal dose (LD50) of test chemical in mouse was found to be 2200 mg/kg of body weight (50 percent mortality observed), 80 percent mortality was seen at dose 2000 mg/kg and 10 percent mortality was seen at 1600 & 1800 mg/kg respectively. Thus considering the CLP criteria for classification it can be assessed that the given test chemical is non toxic via oral route as it exceeds the criteria of 2000 mg/kg bw for the substance to be classified as toxic.
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