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EC number: 224-929-8 | CAS number: 4559-86-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The acute toxicity of tetrabutyl urea to Danio rerio was investigated in a study conducted according to OECD Guideline 203 (Fish, Acute Toxicity Test; 1992). In this semi-static test, 7 fish per concentration were exposed to nominal concentrations of 0, 0.269, 0.538, 1.075, 2.15, and 4.30 mg TBU/L for 96 h. The concentrations of tetrabutylurea in the test media were assessed by chemical analyses (LC/MS/MS). Analysis of test media revealed tetrabutyl urea concentrations between 60.3 and 92.2% of nominal. Therefore, the geometric mean for each test concentration was calculated resulting in actual concentrations of 0.172, 0.365, 1.0, 1.75 and 2.59 mg/L. The 96 h LC50 was determined to be 1.7 mg/L and 1.4 mg/L based on the nominal and geometric mean measured concentrations, respectively.
The acute toxicity of tetrabutyl urea to Daphnia magna was investigated in a study conducted according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test; 2004). In this static test, 20 daphnids per concentration were exposed to nominal concentrations of 0, 0.269, 0.538, 1.075, 2.15, and 4.30 mg TBU/L for 48 h. The concentrations of tetrabutylurea in the test media were assessed by chemical analyses (LC/MS/MS). As the recovered tetrabutyl urea concentrations exceeded the 20 % range at the beginning of the test and decreased more than 20 % from the initial values during the test, the geometric mean for each test concentration was calculated. The 48 h EC50 was determined to be 1.7 mg/L and 1.85 mg/L based on the nominal and geometric mean measured concentrations, respectively.
The toxicity of tetrabutyl urea to the unicellular, green alga Pseudokirchneriella subcapitata was investigated in a study conducted according to OECD Guideline 201 (Alga, Growth Inhibition Test; 2011). In this static test, exponentially growing cultures of the alga were exposed tonominal tetrabutyl urea concentrations of 0 (control), 0.269, 0.538, 1.075, 2.15, and 4.3 mg/L for 72 h. The concentration of tetrabutyl urea was assessed by chemical analysis (LC-MS/MS). As the measured tetrabutyl urea concentrations were outside of the ± 20 % range of the measured initial concentrations for some treatment levels at the end of the study, the geometric mean measured concentrations for each test concentration was calculated. After 72 h of exposure, NOEC values of 0.14 mg/L and 0.58 mg/L were determined for yield and growth rate inhibition, respectively. The 72 h EC50 for yield was determined to be 1.11 mg/L. Since the growth rate inhibition was below 50 % compared to controls at the highest test concentration the 72 h EC50 value was determined to be higher as the highest test concentration (72 h EC50 > 2.95 mg/L; all effect concentrations based on geometric mean measured concentrations).
In a study conducted according to OECD Guideline 209, the respiration inhibition (total respiration, heterotrophic respiration, and respiration due to nitrification) of tetrabutyl urea to activated sludge was found to be low (NOEC>=500 mg/L, LOEC>=1000 mg/L, and EC50>1000 mg/L).
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