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EC number: 420-670-1 | CAS number: 37443-42-8 METHFAT
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From april 22 to april 26, 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl tetrahydro-2-furancarboxylate
- EC Number:
- 420-670-1
- EC Name:
- Methyl tetrahydro-2-furancarboxylate
- Cas Number:
- 37443-42-8
- Molecular formula:
- C6H10O3
- IUPAC Name:
- methyl oxolane-3-carboxylate
- Details on test material:
- Identity: Methfat
Chemical name: Methyl tetrahydro-2-furoate
Batch number: 17-5C03 (GLFC No.002)
Expiry: 7 November 1996
Purity: 99.4%
Appearance: Clear liquid
Storage conditions: In darkness at room temperature
Date received: 17 November 1995
Constituent 1
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Oncorhynchus mykiss
- Source: Westacre Trout Farm, Norfolk, UK.
- Length at study end (mean): 5.1 cm (SD = 0.36 cm)
- Weight at study (mean): 1.81 g (SD = 0.37g)
- Feeding during test: fish were fed daily to repletion but food was not given during the 24 hourperiod immediately prior to exposure or during the exposure period itself.
- Food type: commercial fry pellet
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- calculated from daily measurements during the exposure period = 141 mgCaCO3/l (SD = 8.5 mg)
- Test temperature:
- 15 +/- 2°C
- Dissolved oxygen:
- 9.6 +/- 5 mgO2/l
- Nominal and measured concentrations:
- Nominal concentrations: 4.6, 10, 22, 46 and 100 mg/l
Mean measured concentrations: 4.5, 10, 22, 46 and 99 mg/l
4.6, 10, 22, 46 and 100 mg/1
4.5, 10, 22, 46 and 99 mg/1
- Details on test conditions:
- TEST SYSTEM
- Material, size, headspace, fill volume: Animals were placed at random in glass aquaria containing prepared test media or test water only. Each vessel contained 40 litres of medium to a depth of 26 cm (approximate dimensions of vessel: 52.5 x 32 x 38 cm).
- Aeration: Supplementary aeration was not provided in this study, since methfat was initially considered to be volatile.
- Renewal rate of test solution (frequency/flow rate): Animals were exposed to the test or control conditions for a period of 96 hours with daily batchwise renewal of the teat media to ensure the maintenance of satisfactory environmental conditions and near nominal exposure levels.
- No. of organisms per vessel: Five test concentrations plus one control. Seven animals per test concentration.
- Biomass loading rate: 0.32 g bw/l (static volume)
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Laboratory tap water filtered, dechlorinated and softened by passage through an Elga® water purification system.
- Chlorine: remained below the limit of detection throughout the acclimatisation and exposure periods.
OTHER TEST CONDITIONS
- Photoperiod: 16 h light : 8 h dark
- Treatment and control groups were maintained at 14 ± 1°C throughout the exposure period.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 99 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 6 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 99 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 56 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 41-76 mg/l
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 40 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 28-57 mg/l
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 22-46 mg/l
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 22-46 mg/l
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Measured concentrations ranged from 97- 110% of nominal in fresh media and from 93 - 104% of nominal in expired media, demonstrating that near nominal concentrations were achieved with each media renewal and maintained throughout each subsequent 24 hour exposure period of the study.
Highest test concentration resulting in 0% mortality: 22 mg/l
Lowest test concentration resulting in 100% mortality: 46 mg/l
Marked reactions to exposure (other than death) were increased pigmentation, swimming at surface, loss of equilibrium and slight lethargy.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96 h LC50 value for Methfat with rainbow trout is 32 mg/l. The NOEC is 10 mg/l.
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