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EC number: 937-237-2 | CAS number: 1370006-50-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981-11-27 to 1981-12-14
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Fatty acids, C16-18 (even numbered) and C18 unsatd., reaction products with diethylene triamine, di-Me sulfate quaternized
- Cas Number:
- 1370006-50-0
- Molecular formula:
- Molecular formula cannot be given as substance is a mixture.
- IUPAC Name:
- Fatty acids, C16-18 (even numbered) and C18 unsatd., reaction products with diethylene triamine, di-Me sulfate quaternized
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: BOR: WISW, SPF TNO
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: no data
- Weight at study initiation: male: 165 - 205 g, female: 145 - 165 g
- Fasting period before study: 16 h
- Housing: collective housing up to a maximum of 5 animals per cage (Macrolon type III)
- Diet: ad libitum, Ssniff-R (standard laboratory rat diet)
- Water: ad libitum, tap water
- Acclimation period: 7 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 2
- Humidity (%): 45 - 55
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): aritificial light, 120 Lux, 12 hrs dark / 12 hrs light, from 7:00 to 19:00 light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Range finding: 2.3, 1.5, 0.75 ml
Main test: male: 2.5 - 3.1 ml, female: 2.3 - 2.5 ml - Doses:
- Range finding test: 5, 10, 15 ml/kg
Main test: 15 ml/kg - No. of animals per sex per dose:
- 10 male / 10 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 20 min, 1, 3, 24, 48 h, 7, and 14 d
- Frequency of weighing: day 0 (start), day 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical-toxicological signs (modified Irvin-screening), body weight, section
Results and discussion
- Preliminary study:
- A preliminary rang finding test with a dose of 5, 10, 15 ml/kg bw was conducted using two female rats/dose.
There were no mortalities in the preliminary study.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 15 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no animal died
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 11 250 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: no animal died
- Mortality:
- No mortalities were observed
- Clinical signs:
- other: No abnormal clinical signs were observed
- Gross pathology:
- Gross pathological examinations at 14 days p.a (terminal necropsy) revealed no macroscopic visible organ changes in cranim, thoracic cavity, abdominal cavity.
Any other information on results incl. tables
The original LD 50 for male and female rats is 15 ml/kg bw. Under acceptance of a densitiy of 1 g/cm2 the LD 50 is 15000 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP, EU GHS (Regulation (EC) No 1272/2008)
- Conclusions:
- The partially unsaturated IQAC, DMS quaternised is practically nontoxic based on the LD50 of greater than 11250 mg/kg a.i. body weight.
- Executive summary:
In an acute oral toxicity study (limit test, similar to OECD 401 (February 24, 1987)) 10 male and 10 female rats (BOR: WISW (SPF TNO)) were given a single oral dose of partially unsaturated IQAC, DMS quaternised and observed for 14 days.
Oral LD50 males and females > 15000 mg/kg bw (densitiy 1 g/cm2).
No information on content of active ingredient of the test substance in the study report. However, according to producer information test material has 74 to 77 % a.i., therefore the LD50 refering to 100 % a.i. is 11250 mg/kg bw.
No animal died. No abnormal clinical signs were observed. Weight gains were normal in all animals. Gross pathological examinations at 14 days p.a. (terminal necropsy) revealed no test article-dependent findings.
Partially unsaturated IQAC, DMS quaternised is practically nontoxic based on the LD50in males and females.
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