Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-696-3 | CAS number: 98-73-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data is contained in EU risk assessment report of the substance - credibility is assumed. Reference to origin (Hunter et al.)
Data source
Referenceopen allclose all
- Reference Type:
- other: EU risk assessment report
- Title:
- No information
- Author:
- Federal Institute for Occupational Safety and Health, Division for Chemicals and Biocides Regulation, Germany
- Year:
- 2 009
- Bibliographic source:
- European Union Risk Assessment Report, 4-tert-butylbenzoic acid, CAS No: 98-73-7, EINECS No: 202-696-3, p. 58, Final Approved Version, July 2009
- Reference Type:
- publication
- Title:
- No information
- Author:
- Hunter et al.
- Year:
- 1 965
- Bibliographic source:
- Hunter CG, Chambers PL and Stevenson DE (1965). Studies on the oral toxicity of p-tertbutyl benzoic acid in rats. Fd Cosmet. Toxicol. 3, 289-298.
Materials and methods
- Principles of method if other than guideline:
- 90 d repeated dose oral toxicity study with rats (male/female), uptake of the test substance with the diet, examination of substance-induced effects.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-tert-butylbenzoic acid
- EC Number:
- 202-696-3
- EC Name:
- 4-tert-butylbenzoic acid
- Cas Number:
- 98-73-7
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 4-tert-butylbenzoic acid
- Test material form:
- other: test substance in diet
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth farm
- Sex:
- male/female
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Unscheduled deaths of 9 of ten high dose males occurred by day 34, all females receiving 10000 ppm died by day 53. From the group receiving 3160 ppm, two males died by day 42 and six further males were killed moribund. Two mortalities and one female rat to be killed were also seen in the female group at 3160 ppm. Hematuria has been observed in one male and two females receiving 3160 ppm. Hind limb paralysis was reported for one male and one female exposed to diet concentration of 3160 ppm and one female at 1000 ppm. Kyphosis was observed in three rats receiving 3160 ppm and suspected to occur secondarily to chronic renal failure.
Final body weights were significantly depressed in males at diet concentrations of 316 and above and in female rats at 1000 ppm and above. The feed consumption was reduced in the two top doses to 50-70% of the control values and was not affected in the other dose groups. No treatment-related effect was seen on hematology parameters other than reduced erythrocyte counts in the surviving male treated with 10000 ppm and a shift towards increased percentages of neutrophils and reduction in lymphocyte counts at diet concentrations of 3160 ppm (surviving males and females) and of 10000 ppm (1 male survivor). Clinical chemistry findings showed reduced levels of total protein for male groups receiving 100 to 1000 ppm; urea concentrations were increased in males and female rats at diet concentrations ≥1000 ppm in a dose-related fashion.
Urinalysis revealed increased urine volume and reduced urine osmolality in rats treated with diet concentrations at 3160 ppm and above; protein concentrations were elevated in animals the 10000 ppm dose groups.
Relative organ weights of the liver and the kidneys increased at all diet concentrations. The testes to body ratio decreased in all male dose groups.
Gross findings in dying and sacrificed rats of the two top doses showed congested and speckled livers and hydronephrosis, hydroureter, ureteral obstructions, hematuria in the urinary tract. Bilateral atrophy of the testes was found in males of all dose groups. Microscopically, sinusoidal congestion and fatty degeneration of centrilobular hepatocytes were found (the ‘fatty’ nature was not confirmed by specific staining procedures). Hydronephrosis was confirmed by histopathological examination for males at ≥3160 ppm and female rats at 10000 ppm. Intra-luminal cell debris, necrosis of the tubular epithelium, and papillary necrosis were reported as the causes of the obstructive urinary tract lesions.
Renal tubular necrosis and papillary necrosis was evident in treated male and female rats of all dose groups. The testes atrophy was related to degenerated epithelium of seminiferous tubules.
A NOAEL could not be determined in this early study; 100 ppm (6 mg/kg bw/d for male rat, 8 mg/kg bw/d for female rats) is the LOAEL for oral subchronic administration of 4-tertbutylbenzoic acid.
Applicant's summary and conclusion
- Conclusions:
- According to the results in this study the oral LOAEL of the test substance is 100 ppm (6 mg/kg in male rats, 8 mg/kg in female rats).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.