Registration Dossier
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EC number: 221-659-2 | CAS number: 3179-63-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Acutely harmful to aquatic algae and cyanobacteria.
Key value for chemical safety assessment
- EC50 for marine water algae:
- 16 mg/L
- EC10 or NOEC for freshwater algae:
- 28.2 mg/L
Additional information
In a study following German Industrial Standard DIN 38412, Part 9, the toxicity of DMPA to Desmodesmus subspicatus was investigated. The ErC50 (72 h) was determined to be 51.8 mg/L (72 -h ErC10 = 28.2 mg/L) under not neutralised test conditions (BASF AG, 1989; report no. 89/1743).
The inhibition of algal growth by 3 -dimethylaminopropanol was reduced by adjusting the pH in the test system. Toxic effects of the test substance are probably in part due to an increase in pH at high concentrations of the test substance. The highest concentration of 250 mg/L caused a reduced toxicity of 70% regarding the growth rate compared to 100% of the not-neutralised sample (72-h exposure; biomass: 67% compared to 97%). Based on this information a 72 -h ErC50 of >100 and < 250 mg/L was extrapolated for neutralised conditions.
The test item concentrations were not analytically verified, but are assumed to be stable, due to the the low n-octanol/water partition coefficient (log Kow = -0.23 at 25°C, pH 10.7; log Kow = -2.59 at 25°C, pH 7.2 ), the high water solubility (WS = 1.0E+06 mg/L at 20 °C), the moderate vapour pressure (VP = 1.56 hPa at 20 °C) and the low Henry´s law constant (HLC, uncharged: 0.016 Pa*m³/mol) of the substance.
With regard to the LC/EC50, the effect values show a significantly higher toxicity related to non-neutralised test solutions; therefore, the observed toxicity is partly due to the pH induced by the substance. For risk assessment the effect data for the neutralised test medium should be used, since the quantities of DMPA that would be found in natural waters are not likely to affect the pH to a relevant extent. It is likely that EC50 values from tests without neutralisation overestimate the potential toxicity of the target item.
Furthermore, Eide-Haugmo et al. (2012/2009) performed a guideline study according to ISO 10253 with the marine algae Skeletonema costatum. After 72 hours an ErC50 of 16.0 mg/L was determined.
Based on the lowest available EC50 (marine algae, Skeletonema costatum, ErC50 = 16 mg/L), the substance is assessed to be acutely harmful to aquatic algae.
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