Registration Dossier
Registration Dossier
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EC number: 203-960-0 | CAS number: 112-33-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication but only limited data is given.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 969
Materials and methods
- Principles of method if other than guideline:
- Method: according to Smyth, Carpenter, Weil, Pozzani and Striegel: Range-Finding Toxicity Data: List VI, Amer. Ind. Hyg. Assoc. J. 23: 95 (1962) for details see any other information on materials and methods
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-[2-(3-aminopropoxy)ethoxy]ethanol
- EC Number:
- 203-960-0
- EC Name:
- 2-[2-(3-aminopropoxy)ethoxy]ethanol
- Cas Number:
- 112-33-4
- Molecular formula:
- C7H17NO3
- IUPAC Name:
- 2-[2-(3-aminopropoxy)ethoxy]ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 3-Aminopropoxy-2-ethoxy ethanol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: clipped skin on the trunk
- Type of wrap if used: impervious plastic film
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data - Duration of exposure:
- 24 hours
- Doses:
- no data
- No. of animals per sex per dose:
- 4 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no - Statistics:
- Based upon mortalities during a 14 day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson (Thompson W.R.: Use of Moving Averages and Interpolation to estimate Median Effective Dose, Bacteriol. Rev. 11: 115, June 1947) using Tables of Weil (Weil C. S.: Tables for convenient calculation of Median-Effective Dose (LD50 or ED50) and Instructions in their Use, Biometrics 8: 249, Sept. 1952).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5.99 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 4.27 - 8.42
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 330 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 4 514 - 8 902
- Remarks on result:
- other: calculated using density (chapter 4.4)
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- not determined
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
