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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-103-0 | CAS number: 103-34-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.17 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEL
- Value:
- 8.38 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 4.21 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Step 1) Relevant dose-descriptor: NOAEC (rat, 90d) = 8.38 mg/m3 for systemic effects. Step 2) Modification of starting point: * Correction of respiratory volume for relevant duration: For 8h of exposure, the respiratory volume of humans is 6.7 m3/ person, and the respiratory volume light activity for worker (8h exposure) is 10 m3/person. The correction factor is 6.7/10. * Correction or exposure duration in study (6h/d, 5d/wk) to default worker exposure (8h/d, 5d/wk): The correction factor is 6/8. * Correction for absorption difference between rat and human: No difference in inhalation absorption is expected between rats and humans. NOAEC corrected = 8.38 x 6/8 x 6.7/10 = 4.21 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- This factor is applied because the dose-descriptor starting point is a NOAEC.
- AF for differences in duration of exposure:
- 2
- Justification:
- DNEL is based on a subchronic study (90-day).
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- AF not used for inhalation.
- AF for other interspecies differences:
- 2.5
- Justification:
- A factor of 2.5 is applied for remaining difference.
- AF for intraspecies differences:
- 5
- Justification:
- A factor of 5 is applied for worker DNELs.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study chosen for DNEL calculation is considered as a reliable study.
- AF for remaining uncertainties:
- 1
- Justification:
- No other assessment factor is applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- By inhalation
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.02 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Dose descriptor:
- NOAEC
- Value:
- 0.507 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- This factor is applied because the dose-descriptor starting point is a NOAEC.
- AF for differences in duration of exposure:
- 1
- Justification:
- Not applicable for local effects.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- AF not used for inhalation.
- AF for other interspecies differences:
- 2.5
- Justification:
- A factor of 2.5 is applied for remaining difference.
- AF for intraspecies differences:
- 5
- Justification:
- A factor of 5 is applied for worker DNELs.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study chosen for DNEL calculation is considered as a reliable study.
- AF for remaining uncertainties:
- 1
- Justification:
- No other assessment factor is applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.024 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEC
- Value:
- 8.38 mg/m³
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 2.41 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Step 1) Relevant dose-descriptor: NOAEC, rat = 8.38 mg/m3 for systemic effects. Step 2) Modification of starting point: * Correction for absorption difference between rat and human, and between dermal and inhalation absorption:No difference in dermal and inhalation absorption is expected between rats and humans. A default inhalation and dermal absorption of 100% in rats and humans is used for DNEL derivation. * Correction of respiratory volume for relevant duration: For a 6-h exposure, the respiratory volume of rats is 0.288 m3/kg bw. NOAEL (internal dose) = 8.38 x 0.288 = 2.41 mg/kg bw
- AF for dose response relationship:
- 1
- Justification:
- This factor is applied because the dose-descriptor starting point is a NOAEL.
- AF for differences in duration of exposure:
- 2
- Justification:
- DNEL is based on a subchronic study (90-day).
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- An allometric scaling factor of 4 must be applied because the key study was performed on rats.
- AF for other interspecies differences:
- 2.5
- Justification:
- A factor of 2.5 is applied for remaining difference.
- AF for intraspecies differences:
- 5
- Justification:
- A factor of 5 is applied for worker DNELs.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study chosen for DNEL calculation is considered as a reliable study.
- AF for remaining uncertainties:
- 1
- Justification:
- No other assessment factor is applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.03 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Dose descriptor starting point:
- NOAEC
- Value:
- 8.38 mg/m³
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1.5 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Step 1) Relevant dose-descriptor: NOAEC (rat, 90d) = 8.38 mg/m3 for systemic effects. Step 2) Modification of starting point: * Correction or exposure duration in study (6h/d, 5d/wk) to default general population exposure (24h/d, 7d/wk) :The correction factor is 6/24 x 5/7. * Correction for absorption difference between rat and human: No difference in inhalation absorption is expected between rats and humans. NOAEC corrected = 8.38 x 6/24 x 5/7 = 1.50 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- This factor is applied because the dose-descriptor starting point is a NOAEC.
- AF for differences in duration of exposure:
- 2
- Justification:
- DNEL is based on a subchronic study (90-day).
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- AF not used for inhalation.
- AF for other interspecies differences:
- 2.5
- Justification:
- A factor of 2.5 is applied for remaining difference.
- AF for intraspecies differences:
- 10
- Justification:
- A factor of 10 is applied for the general population DNELs.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study chosen for DNEL calculation is considered as a reliable study.
- AF for remaining uncertainties:
- 1
- Justification:
- No other assessment factor is applied.
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- By inhalation
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.004 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor:
- NOAEC
- Value:
- 0.507 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- This factor is applied because the dose-descriptor starting point is a NOAEC.
- AF for differences in duration of exposure:
- 1
- Justification:
- DNEL is based on a subchronic study (90-day).
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- AF not used for inhalation.
- AF for other interspecies differences:
- 2.5
- Justification:
- A factor of 2.5 is applied for remaining difference.
- AF for intraspecies differences:
- 10
- Justification:
- A factor of 10 is applied for the general population DNELs.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study chosen for DNEL calculation is considered as a reliable study.
- AF for remaining uncertainties:
- 1
- Justification:
- No other assessment factor is applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.012 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEC
- Value:
- 8.38 mg/m³
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 2.41 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Step 1) Relevant dose-descriptor:NOAEC (rat,90d) = 8.38 mg/m3 for systemic effects. Step 2) Modification of starting point: * Correction for absorption difference between rat and human, and between dermal and inhalation absorption: A default inhalation and dermal absorption of 100% in rats and humans is used for DNEL derivation. Thereforethe correction factor is 1 (100/100 = 1). * Correction of respiratory volume for relevant duration: For 6h of exposure, the respiratory volume of rats is 0.288m3/kg bw. NOAEL (internal dose) = 8.38 x 0.288 = 2.41 mg/kg bw
- AF for dose response relationship:
- 1
- Justification:
- This factor is applied because the dose-descriptor starting point is a NOAEL.
- AF for differences in duration of exposure:
- 2
- Justification:
- DNEL is based on a subchronic study (90-day).
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- An allometric scaling factor of 4 must be applied because the key study was performed on rats.
- AF for other interspecies differences:
- 2.5
- Justification:
- A factor of 2.5 is applied for remaining difference.
- AF for intraspecies differences:
- 10
- Justification:
- A factor of 10 is applied for the general population DNELs.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study chosen for DNEL calculation is considered as a reliable study.
- AF for remaining uncertainties:
- 1
- Justification:
- No other assessment factor is applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.012 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEC
- Value:
- 8.38
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 2.41 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Step 1) Relevant dose-descriptor: NOAEC (rat, 90d) = 8.38 mg/m3 for systemic effects. Step 2) Modification of starting point: * Correction for absorption difference between rat and human, and between oral and inhalation absorption: A default inhalation and oral absorption of 100% in rats and humans is used for DNEL derivation. * Correction of respiratory volume for relevant duration: For 6h of exposure, the respiratory volume of rats is 0.288m3/kg bw. NOAEL (internal dose)= 8.38 x 0.288 = 2.41 mg/kg bw/d
- AF for dose response relationship:
- 1
- Justification:
- This factor is applied because the dose-descriptor starting point is a NOAEL.
- AF for differences in duration of exposure:
- 2
- Justification:
- DNEL is based on a subchronic study (90-day).
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- An allometric scaling factor of 4 must be applied because the key study was performed on rats.
- AF for other interspecies differences:
- 2.5
- Justification:
- A factor of 2.5 is applied for remaining difference.
- AF for intraspecies differences:
- 10
- Justification:
- A factor of 10 is applied for the general population DNELs.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study chosen for DNEL calculation is considered as a reliable study.
- AF for remaining uncertainties:
- 1
- Justification:
- No other assessment factor is applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.