3,4-dichlorobenzonitrile

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

2008

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

There is no data available acute dermal toxicity testing with 3,4-Dichlorobenzonitrile. In order to classify the substance according to GHS relevant endpoint data available for 2,6-Dichlorobenzonitrile was read-acrossed to 3,4-Dichlorobenzonitrile based on structural similarities. 2,6-Dichlorobenzonitrile is as well as 3,4-Dichlorobenzonitrile, is a disubstituted Benzonitrile. Both substances only differ in the position of the chloro substituents. Furthermore both substances are solid, practically insoluble in water and have a water octanol partition coefficient of 2.2 and 2.8. This might perhaps also lead to a similiar dermal resorption of the substnces and therefore a similar toxicological behavior. In order to gain more information about 3,4-Dichlorobenzonitrile and to classify the substance (without any unneccessary animal testing) according to GHS the result of the acute dermal test with 2,6-Dichlorbenzonitrile was read acrossed.
For justsification of Read Across see section 13.2

Data source

Reference

Reference 1

Reference Type:

other: Chemical Toxicity Database

Title:

No information

Year:

2008

Bibliographic source:

RTECS number-DI3500000-Chemical Toxicity Database (www.drugfuture.com/toxic/q28-q540.html)

Reference 2

Reference Type:

publication

Title:

No information

Author:

The European Parliament and the Council

Year:

2008

Bibliographic source:

Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures.

Report date:

2008

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: no guideline rreported

Principles of method if other than guideline:

The data was collected from a database only in order to classify the substance.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Dichlobenil

EC Number:

214-787-5

EC Name:

Dichlobenil

Cas Number:

1194-65-6

Molecular formula:

C7H3Cl2N

IUPAC Name:

2,6-dichlorobenzonitrile

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 350 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Executive summary:

There is no data available on dermal toxicity testing with 3,4 -Dichlorobenzonitrile. In order to classify the substance (without any unnecessary animal testing) according to GHS relevant endpoint data for 2,6 -Dichlorobenzonitrile was read-acrossed to 3,4 -Dichlorobenzonitrile based on structural and physico chemical similarities (see rationale for reliability).

2,6 -Dichlorobenzonitrile is officially classified as acute Tox. 4 H312 ("Harmful in contact with skin"). Furthermore a entry in the Chemical Toxicity Database "RTECS number-DI3500000" refers a LD50 value of 1350 mg/kg, which also requires a classification as acute Tox. 4 H312.

Therefore and because of the same classification 2 -Chlorobenzonitrile in dermal toxicity, 3,4 -Dichlorobenzontrile was also classified as acute Tox. 4 H312.