Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-697-2 | CAS number: 12542-30-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 29 Jun - 13 Sep 1966
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
- Principles of method if other than guideline:
- The study was conducted following a protocol based on BASF-internal standards.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Hexahydro-4,7-methano-1H-indenyl acrylate
- EC Number:
- 235-697-2
- EC Name:
- Hexahydro-4,7-methano-1H-indenyl acrylate
- Cas Number:
- 12542-30-2
- Molecular formula:
- C13 H16 O2
- IUPAC Name:
- 2-Propenoic acid hexahydro-4,7-methano-1H-indenyl ester
- Details on test material:
- Name of the test substance used in the study report: Dihydrodicyclopentadienylacrylat roh
Analytical purity: no data given
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mice described as "Kisslegg"-Mice (not clear if supplier, strain etc. is meant)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- The test substance was administered in concentrations of 2, 8, 20 or 30% (aqueous emulsion with traganth)
- Doses:
- 200, 400, 800, 1000, 1250, 1600, 3200 µl/kg bw
(corresponding to 216, 432, 864, 1080, 1350, 1728, 3456 mg/kg bw; density of substance 1.08 g/cm3) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 404 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Two lowest dose groups: no mortalities.
1080 mg/kg bw: 2/10 after 7 days
1350 mg/kg bw: 4/10 after 7 days
1728 mg/kg bw: 7/10 after 7 days
3456 mg/kg bw: all animals died
LD50: 1404 mg/kg bw (1.3 ml/kg bw) - Clinical signs:
- 3456 mg/kg: 2 h after injection abdominal position. Narcosis-like condition. Crampy convulsions.
1728, 1350, 1080 mg/kg bw: day of injection similar to highest dose group without narcosis-like condition. Hindlimbs sprawled out. Irregular respiration. Moderate tremor. Eyes stuck shut. Piloerection. Clinical signs were reversible in the animals that survived. - Gross pathology:
- After necropsy, nothing abnormal was detected.
Any other information on results incl. tables
Table 1: Mortality rates after application (i.p.) of test substance to male and female mice.
Dose (µl/kg bw) |
Dose (mg/kg bw) |
Conc. (%) |
Number of animals |
Number of dead animal within |
|||||
|
|
|
|
1 h |
24 h |
48 h |
7 d |
14 d |
|
3200 |
3456 |
30 |
10 |
0/10 |
10/10 |
10/10 |
10/10 |
- |
|
1600 |
1728 |
20 |
10 |
0/10 |
1/10 |
3/10 |
7/10 |
- |
|
1250 |
1350 |
20 |
10 |
0/10 |
1/10 |
3/10 |
4/10 |
- |
|
1000 |
1080 |
20 |
10 |
0/10 |
0/10 |
1/10 |
2/10 |
- |
|
800 |
864 |
8 |
10 |
0/10 |
0/10 |
0/10 |
0/10 |
- |
|
400 |
432 |
8 |
10 |
0/10 |
0/10 |
0/10 |
0/10 |
- |
|
200 |
216 |
2 |
10 |
0/10 |
0/10 |
0/10 |
0/10 |
- |
|
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.