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EC number: 224-923-5 | CAS number: 4553-62-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: not irritating according to the test information. However, taking into account that the
composition and purity of the test material was not reported, it is unknown whether the test
substance contained cresol in the same amount as the industrial product. The presence of <3%
cresol triggers skin irritation cat 2.
Eye irritation: slightly irritating according the test information. However, taking into account that the
composition and purity of the test material was not reported, it is unknown whether the test
substance contained cresol in the same amount as the industrial product. The presence of <3%
cresol triggers eye irritation cat 2.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
Three studies were available. Two of them were considered as not reliable (Kr: 3) and a study of Guilot, 1981 was identified as the key study (Kr: 2)
This skin irritation and corrosion study was performed similarly to the OECD test guideline No. 404 (Draize test). 4 New Zealand White rabbits were exposed to 0.5 mL of undiluted 2-Methylglutaronitrile. Intact and abraded skin of each animal (2 different sites) was in contact with the test substance. Test sites were covered with an occlusive dressing for 24 hours and weren’t washed after this period. Changes were observed at 25 and 72 hours (1 hr and 48 hr after the dressing removal). Mean score of intact skin were 0.0 for erythema and edema. Thus 2 -methylglutaronitrile is considered as not irritating to the skin.
Taking into account that the composition and purity of the test material was not reported, it is unknown whether the test substance contained cresol in the same amount as the industrial product. The presence of <3% cresol triggers skin irritation cat 2.
Eye irritation:
Two studies were available. One of them was considered as not assignable (Kr: 4). A key study was identified (Guillot, 1981). In an eye irritation study performed similarly to the OECD test guideline No. 405 (Draize test), 0.1 mL of undiluted 2-Methylglutaronitrile was instilled into the conjunctival sac of left eye of 4 New Zealand White rabbits. The eyes of the animals were not rinsed after instillation. Changes were observed at 1, 24, 48, 72, 96 and 168 hours after dosing and grading according to Draize scale. 2-Methylglutaronitrile produced chemosis (mean score 0.42), conjunctival redness (mean score 0.25), corneal lesions (mean score 0.25), and iris lesions (mean score 0.25). All of these effects were totally reversed after 3 days. Therefore 2 -methylglutaronitrile is considered as slightly irritating.
Taking into account that the composition and purity of the test material was not reported, it is unknown whether the test substance contained cresol in the same amount as the industrial product. The presence of <3% cresol triggers eye irritation cat 2.
Respiratory irritation:
No data was available.
Effects on eye irritation: slightly irritating
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
2 -Methylglutaronitrile is not classified in the Annex VI of the CLP regulation (1272/2008). A self-classification is proposed as followed:
1-Skin irritation:
As no signs of skin irritation were observed in a dermal irritation study with 2-Methylglutaronitrile conducted similarly to OECD test guideline No. 404, 2-Methylglutaronitrile is considered as not irritating to the skin according to the CLP Regulation (1272/2008) and to the Directive 67/548/EC.
2- Eye irritation:
- Not irritating according to the CLP Regulation (1272/2008) as the mean scores obtained in the key study (OECD 405) were all under the limit scores (1 or 2 depending on the observed parameter) for classification.
- Not irritating according to the Directive 67/548/EEC as the mean scores obtained in the key study (OECD 405) were all under the limit scores (1, 2 or 2.5 depending on the observed parameter) for classification.
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