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Diss Factsheets
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EC number: 902-591-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low octanol water partition coefficient and the adsorption potential of this substance is related to this parameter
- Endpoint:
- adsorption / desorption: screening
- Remarks:
- adsorption
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The adsorption of methanol onto different soil types was studied at 6°C by use of a batch procedure.
- GLP compliance:
- no
- Type of method:
- batch equilibrium method
- Media:
- soil
- Radiolabelling:
- yes
- Test temperature:
- 6°C
- Analytical monitoring:
- no
- Key result
- Type:
- Koc
- Value:
- >= 0.13 - <= 0.61 L/kg
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The Koc for the test item ranged between 0.13 and 0.61for different soil types and concentrations.
- Executive summary:
The adsorption of methanol onto three different soil types was messured at 6 °C. Only slight methanol adsorption occurred with the two sandy soils tested (percentage organic matter of 0.09% and 0.1% in the samples) and with the clay soil (percentage organic matter was 0.22%). Methanol solutions of concentration 0.1, 1.0, 9 and 90 mg/L were used in 1 hour exposure adsorption studies and adsorption coefficients of between 0.13 and 0.61 were measured for all soil types and at all concentrations. These coefficients indicate that methanol has a low adsorptive capacity on soils.
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- Please refer to IUCLID section 13 for Read Across Justification.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Type:
- Koc
- Value:
- >= 0.13 - <= 0.61 L/kg
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- Please refer to IUCLID section 13 for Read Across Justification.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Type:
- log Koc
- Value:
- 0.18 dimensionless
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 23.03.2007 - 28.03.2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Test temperature:
- 40°C +/- 0.5°C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus:
- Type: Agilent 100
- Type, material and dimension of analytical (guard) column: LiChrospher 100 CN 5 µm, L = 250 mm, ID = 4 mm
- Detection system: DAD at 210.4 nm
MOBILE PHASES
- Type: 20 % (v/v) acetonitrile / 80 % (v/v) water; flow rate 1 ml/min, isocratic
- pH: 7
- Solutes for dissolving test and reference substances: dissolved in the mobile phase
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column (thiourea)
REFERENCE SUBSTANCES
- Identity: as recommended in the guideline: thiourea (1.254 mg/ml), acetanilide (0.147 mg/ml), atrazine (0.0946 mg/ml), triadimenol (0.1092 mg/ml), monuron (0.1478 mg/ml), linuron (0.1076 mg/ml), pyrazophos (0.1208 mg/ml)
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: concentration of test substance 3.9796 mg/ml, injection volume 5 µl
- Quantity of reference substances: injection volume 5 µl
REPETITIONS
- Number of determinations: 10 injections, each substance determined in duplicate
EVALUATION
- Calculation of capacity factors k': k' = (tR-t0)/t0
- Calculation of retention times: mean of 2 measurements
- Determination of the log Koc value: log k' values of the reference substances were plotted against their log Koc values as stated in the guideline. The Koc value of methyl acetate was determined by using this plot - Key result
- Type:
- log Koc
- Value:
- 0.18 dimensionless
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: see table
- Details of fitted regression line (log k' vs. log Koc): equation of regression line: y = 1.7945x + 1.3607; R² = 0.9616
- Average retention data for test substance: Average retentione time 3.088 - Transformation products:
- not specified
- Statistics:
- not specified
- Validity criteria fulfilled:
- not applicable
- Remarks:
- a reproducible method was used
- Conclusions:
- In a study according to OECD TG 121 and EU Method C.19 (HPLC Method) the Log Koc of the test item was determined to be 0.18.
- Executive summary:
The adsorption coefficient of Methyl acetate was determined by HPLC method according to OECD TG 121 and EU Method C.19. The test substance as well as well as 7 reference substances were dissolved in a mixture of acetonitrile and water. Thiourea was used to define the dead time. Each substance was measured in duplicate and their capacitiy factors k' were calcuated. The log k' value were plotted against the respective log Koc values of the reference substances. The log Koc value of Methyl acetate was calculated by means of the regression line equation resulting in 0.18.
Referenceopen allclose all
Table 1: Mean retention times of the reference substances
Substance |
Mean retention time [min] |
Thiourea |
2.533 (= dead time) |
Acetanilide |
4.498 |
Atrazine |
7.624 |
Triadimenol |
15.302 |
Monuron |
7.351 |
Linuron |
16.368 |
Pyrazophos |
39.753 |
Description of key information
The study does not need to be conducted because the registration substance has a low octabol water partitioning coefficient and the adsorption potential of this substance is related to this parameter (study scientifically not necessary). However, based on a read across approach to Methyl acetate the Koc of the registration substance was determined to be 1.51 L/kg.
Key value for chemical safety assessment
- Koc at 20 °C:
- 1.51
Additional information
The octanol water partitioning coefficient of the registration substance was determined to be Log Kow = 0.18 (please refer to IUCLID section 4.7). In accordance with column 2 of Annex VIII to Regulation (EC) No 1907/2006 (REACH) the study on adsorption/desorption screening does not need to be conducted if "based on the physico-chemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient)". The very low octanol water partition coefficient of the registration substance indicates that the registration substance has a low potential for adsorption.
Nevertheless, supporting information for the read across source substances Methanol and Methyl acetate are available and summarized below.
Supporting information
Lokke (1984) studied the adsorption of methanol onto three different soil types at 6 °C. Adsorption coefficients of between 0.13 and 0.61 L/kg were measured for all soil types and at all concentrations. This results shows that Methanol has a low adsorptive capacity on soils.
The adsorption coefficient of Methyl acetate was determined by HPLC method according to OECD TG 121 and EU Method C.19 (Wieser, 2007). The capacity factors k' were calculated and plotted against the respective log Koc values of the reference substances. The Log Koc value of methyl acetate was calculated by means of the regression line equation resulting in 0.18 which corresponds to a Koc of 1.51 L/kg.
Conclusion
The study is considered scientifically not necessary because the registration substance has a low octanol water partitioning coefficient and was hence waived. Nevertheless, following a worst case approach, a Koc of 1.51 L/kg was derived based on supporting information for the read across source substance Methyl acetate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.