Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 608-544-6 | CAS number: 3082-64-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Skin (in vivo)
(S)-1 -Phenyl-propylamine (CAS 3789-59-1, read across) was highly corrosive after application on rabbit skin (OECD 404). [Calvert Preclinical Services, 2001]
Eye (ex vivo)
(S)-1 -Phenyl-propylamine (CAS 3789-59-1, read across) was irritating after application on rabbit eyes. [Calvert Preclinical Services, 2000]
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Currently, there are no studies available regarding skin and eye irritation. Nevertheless, there are two reliable studies existing, which may serve as read across for each endpoint: (S)-1 -Phenyl-propylamine (CAS 3789-59-1).
Skin
The potential of (S)-1-Phenylpropylamine (CAS 3789-59-1, read across) to cause acute dermal irritation or corrosion was assessed in vivo in rabbits. The test substances caused full thickness necroses within an exposure time of 3 min. [Calvert Preclinical Services, 2001]
Eye
A study was performed to assess the ocular irritancy potential of (S)-1-Phenylpropylamine (CAS 3789-59-1, read across) in the rabbit following application onto the cornea of the enucleated eye. The rabbit enucleated eye test is used, as a first stage in the assessment of ocular irritancy potential. Based on the evaluation criteria defined for this test, the test substance was considered to have the potential to cause ocular irritancy in vivo. [Calvert Preclinical Services, 2000]
Respiratory system
Currently, there is no information available.
Effects on skin irritation/corrosion: highly corrosive
Effects on eye irritation: irritating
Justification for classification or non-classification
Based on the available data for (S)-1-Phenyl-propylamine (CAS 3789-59-1, read across), (R)-1-Phenyl-propylamine is subject to C&L:
Skin
according to Regulation 1272/2008/EC: highly corrosive to the skin and eyes: cat. 1A (H314)
according to Directive 67/548/EEC: causes severe burns: R35
Eye
In view of the results of the skin irritation test, the test substance is also considered as corrosive to the eye:
according to Regulation 1272/2008/EC: highly corrosive to the skin and eyes: cat. 1A (H314)
according to Directive 67/548/EEC: causes severe burns: R35
Respiratory system
No data available. The substance is corrosive
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)