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Diss Factsheets
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EC number: 449-400-0 | CAS number: 25822-43-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Discussion
The acute aquatic toxicity of the test item was investigated for fish, Daphnia and algae. The test item was not water soluble and therefore tested as suspension. No signs of toxicity were observed. The test item is considered to be not acute toxic for the aquatic system.
Short- term toxicity to fish
The acute toxicity of the test item to fish was investigated in a static system using Brachidanio rerio (Danio rerio (EEC/92/69, C.1)). No mortality was observed after the exposure period of 96 hours. The LC50 was estimated to be > 100 mg/L and NOEC was determined to be 100 mg/L. The test item is considered to be not toxic to fish.
Long-term toxicity to fish
The performance of a test for long-term toxicity to fish was considered scientifically not justified.
REACH Regulation (EC) No 1907/2006, Annex VIII, Sect. 9.1.3, Col. 2, states as follows: 9.1.3: The study (long-term toxicity to fish) does not need to be conducted if:
- there are mitigating factors indicating that aquatic toxicity is unlikely to occur, for instance if the substance is highly insoluble in water or the substance is unlikely to cross biological membranes”
The test item is practically insoluble in aquatic environment. In addition, based on the high Log Pow of 9.2, the substance is very unlikely to pass biological membranes. The substance is not toxic to all 3 trophic levels in acute tests. Therefore, the substance is not expected to be toxic in chronic tests. Thus, the CSR does not show a need for an additional long-term aquatic test. Risk assessment is based on the short-term tests for all trophic levels.
Short- term toxicity to aquatic invertebrates
Acute toxicity of the test item was investigated in a static test using Daphnia magna as model system (EEC/92/69, C.2). The test item was insoluble in water. No toxicity was observed for 100 mg/L nominal concentration after exposure period of 48 hours. The EC50 was estimated to be > 100 mg/L. The NOEC was determined to be 100 mg/L. The test item is considered to be not toxic to aquatic invertebrates.
Long-term toxicity to aquatic invertebrates
REACH Regulation (EC) No 1907/2006, Annex IX, Sect. 9.1, Col. 2, states as follows:
“9.1.: Long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms. The choice of the appropriate tests(s) depends on the results of the chemical safety assessment."
A study assessing the long-term toxicity of the test item CCPIB towards aquatic invertebrates (Daphnia sp.) according to OECD 211 guideline is currently not available. The studies assessing the short-term toxicity of the test item towards fish, aquatic invertebrates (Daphnia sp.) and algae clearly show no adverse effects up to the test item's water solubility. In addition, based on the high Log Pow of 9.2, the substance is very unlikely to pass biological membranes. The substance is not toxic to all 3 trophic levels in acute tests Therefore, the substance is not expected to be toxic in chronic tests.
Short- term toxicity to algae and cyanobacteria
The test item was investigated for its acute toxicity in a static test system using Selenastrum capricornutum (EU- Method, C.3). The test item was not water soluble. After the 72 hour exposure no signs of toxicity were observed. The EC50 was estimated to be > 300 mg/L and NOEC was determined to be 100 mg/L. The test item is considered to be not toxic for algae.
Toxicity to microorganisms
The test item was investigated for its toxicity to microorganisms following OECD209. The test item did not inhibit respiration of activated slugde within the exposure period of 3 hours. The EC50 was estimated to be > 300 mg/L and NOEC / EC10 was determined to be 300 mg/L. The test item is considered to be not toxic to microorganisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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