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Diss Factsheets
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EC number: 217-031-2 | CAS number: 1724-39-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of cyclic 12-, 8- and 6-carbon compounds on glutathione S-transferase activity
- Author:
- Sparnins VL, Lam LKT and Wattenberg LW
- Year:
- 1 984
- Bibliographic source:
- Biochem. Biophys. Res. Commun. 120, 2, 637-640
Materials and methods
- Principles of method if other than guideline:
- Glutathione S-transferase is considered as a major detoxification system which catalyzes conjugation of electrophilic compounds, e.g. chemical
carcinogens, to glutathione. The effects of cyclic 12-, 8- and 6-carbon compounds (incl. cyclododecanol) on the glutathione S-transferase
(E.C 2.5.1.18) activity in the liver, intestinal mucosa and the forestomach of female ICR/Ha mice were investigated. - GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Cyclododecanol
- EC Number:
- 217-031-2
- EC Name:
- Cyclododecanol
- Cas Number:
- 1724-39-6
- Molecular formula:
- C12H24O
- IUPAC Name:
- cyclododecanol
- Details on test material:
- Cyclododecanol from Aldrich Chemical Company, purity not reported
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISM
- Female ICR/Ha mice
- Age: 7 weeks - Number: 5-10 animals per group
- Control: diet
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: semipurified diet
- Details on exposure:
- TREATMENT - 30 or 50 µmol/g in diet for 2 weeks
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 2 weeks
- Frequency of treatment:
- 2 weeks
- Post exposure period:
- no
Doses / concentrations
- Remarks:
- Doses / Concentrations:
30 or 50 µmol/g
Basis:
- No. of animals per sex per dose:
- 5 - 10
- Control animals:
- yes, plain diet
- Details on study design:
- no further details
Examinations
- Examinations:
- EXAMINATIONS
- Removal and homogenization of liver, forestomach, and mucosa from small bowel
- GST activity determination using 1-chloro-2,4-dinitrobenzene as substrate - Positive control:
- no positive control
Results and discussion
- Details on results:
- None of the compounds elicited increased GST activity in the forestomach. C6 ring compounds showed no significant effect. C12 ring compounds
were more effective than C8 ring compounds with a decrease in activity in the order: unsaturated > epoxide > alcohol > saturated.
Any other information on results incl. tables
-----------------------------------------------------------
Test compound Liver Small Bowel Mucosa
Specific Activity Specific Activity
------------------------------------------------------------
None
1.96 +- 0.16 0.61 +- 0.04
Cyclododecanol 3.21 +- 0.11* 1.07 +- 0.02*
* = p <0.005
Applicant's summary and conclusion
- Conclusions:
- None of the compounds elicited increased GST activity in the forestomach.
- Executive summary:
None of the compounds elicited increased GST activity in the forestomach. C6 ring compounds showed no significant effect. C12 ring compounds were more effective than C8 ring compounds with a decrease in activity in the order: unsaturated > epoxide > alcohol > saturated.
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