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Diss Factsheets
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EC number: 200-143-0 | CAS number: 52-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Scientifically acceptable. Update of earlier (1980) Safety Assessment. Special emphasis on potential reactions with other ingredients, i.e. triethanolamine, which might lead to nitroso compounds, and toxicological findings related to such nitroso compounds.
Data source
Reference
- Reference Type:
- publication
- Title:
- Addendum to the Final Report on the Safety Assessment of 2-Bromo-2-Nitropropane-1,3-Diol
- Author:
- Anonymous
- Year:
- 1 984
- Bibliographic source:
- Cited in: Cosmetic Ingredient Review, Journal of the American College of Toxicology, Vol. 3, No: 3: 139-155, (Published), BPD ID B6.6_01
Materials and methods
- Type of study / information:
- Type: other: Review; Addendum to Safety Assessment Report Bronopol (Safety assessment of 2-bromo-2-nitropropane-1,3 -diol)
- Principles of method if other than guideline:
- Data on occupational exposure of worker to Bronopol
Test material
- Reference substance name:
- Bronopol
- EC Number:
- 200-143-0
- EC Name:
- Bronopol
- Cas Number:
- 52-51-7
- Molecular formula:
- C3H6BrNO4
- IUPAC Name:
- 2-bromo-2-nitropropane-1,3-diol
Constituent 1
Results and discussion
Any other information on results incl. tables
Twenty out of fifty bronopol exposed workers suffered from skin irritation and/or superficial burns. In 8 cases a second occurrence, in 6 cases, a third occurrence and in 3 cases, a fourth occurrence were reported. The reported findings were described as irritant reaction rather than contact allergy.
The earlier conclusion is reaffirmed that Bronopol is safe as a cosmetic ingredient at concentrations up to 0.1% except from circumstances where reactions with amines or amides can result in nitrosamine or nitrosamide formation.
Applicant's summary and conclusion
- Conclusions:
- The earlier conclusion is reaffirmed that Bronopol is safe as a cosmetic ingredient at concentrations up to 0.1% except from circumstances where reactions with amines or amides can result in nitrosamine or nitrosamide formation.
- Executive summary:
In a safety assessment (Anonymous, 1984), data on occupational exposure of 50 workers to Bronopol were reported.The skin of 20/50 Bronopol exposed workers showed signs of skin irritation and/or superficial burns following exposure to saturated aqueous solutions or powder of Bronopol on at least one occasion. In 8 cases a second occurrence, in 6 cases, a third occurrence and in 3 cases, a fourth occurrence were reported. None of the concerned workers had quit the job because of these injuries. Conclusively, the reported findings were described as irritant reaction rather than contact allergy.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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