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EC number: 612-179-8 | CAS number: 61597-98-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No valid study for menthyl lactate is available. Therefore read-across to the structural very similar menthyl acetate was done. Based on experimental data obtained for menthyl acetate, the EC50 growth rate was determined to be 3.11 mg/L for menthyl lactate. The EC10 growth rate is 0.7 mg/L, the NOEC growth rate is 0.18 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 3.11 mg/L
- EC10 or NOEC for freshwater algae:
- 0.7 mg/L
Additional information
A valid study on algal toxicity with menthyl lactate is not available. Therefore read-across to the structural very similar menthyl acetate was done. The influence of the menthyl acetate racemic on the growth of the freshwater green algal species Pseudokirchneriella subcapitata was investigated in a 72-hour static test according to the OECD Guideline 201 (2006) and the Commission Regulation (EC) No 761/2009, C.3. The preparation of the test media was based on the OECD Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures, 2000. At the start of the test, the analytically determined concentrations of Menthyl Acetate racemic in the test media were 0.0368, 0.127, 0.35, 1.27, 4.12 and 13.2 mg/L, respectively. During the test period of 72 hours, a decrease of test item concentration in the test media occurred. At the end of the test, the measured test item concentrations in the test media with algae (dilutions 1:320 to 1:3.2) were below the Limit of Quantification (LOQ=0.0218 mg/L). In the undiluted filtrate with algae, 12.5 mg/L was found. Additionally, the test media were incubated over the test duration, but without algae. The measured test item concentrations in the test media without algae (dilutions 1:320 to 1:3.2) were below the LOQ. In the undiluted filtrate without algae, 9.2 mg/L was found. Therefore the losses in the test media with algae during the test period were not considered to be due to adsorption of the test item onto the algae.
Since most of the test item was degraded at the end of the test, the analytical measurements were also based on Menthol rac. (CAS 89-78-1), a degradation product of the test item. At the end of the test, the total determined concentrations of Menthol rac. (expressed as test item) plus test item were 0.0596, 0.191, 0.58, 1.955, 4.999 and 13.26 mg/L, respectively. The biological results were related to the mean measured test item concentrations calculated as the geometric means of the concentrations measured at the start (test item concentration) and end (Menthol rac. concentrations expressed as test item + test item) of the test.
The biological results (based on geometric mean measured concentrations of menthyl acetate) of the study were as follows: EC50 growth rate is 2.7 mg/L. EC10 growth rate is 0.61 mg/L. NOEC growth rate is 0.16 mg/L. After adjustment to the molecular weight of menthyl lactate (228.33, compared to 198.3 of menthyl acetate), these results correspond to an estimated ErC50 value of 3.11 mg/L, an estimated ErC10 value of 0.7 mg/L and a NOEC of 0.18 mg/L for menthyl lactate. This conclusion is also supported by a valid study with L-menthol (Bruns, Caspers 2002b) (for applicability of read across refer to justification document in chapter 13).
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