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EC number: 500-446-0 | CAS number: 160901-09-7 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other:
- Remarks:
- Result derived from a (Q)SAR model with no adequate performance in internal validation, but the reliability and adequacy of the result is supported by similar substances from the model training set with experimental data. Thus the target prediction is in line with experimental data of the most similar substances and therefore the prediction is considered valid.
- Justification for type of information:
- 1. SOFTWARE
Microsoft Excel, version 2016
2. MODEL (incl. version number)
FISH EC10 C/EO QSAR mass based toxic unit additivity
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See “Test material information”
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Information on the compliance with the OECD criteria is provided in the attached QMRF.
5. APPLICABILITY DOMAIN
See information as provided in the attached QMRF and QPRF.
6. ADEQUACY OF THE RESULT
See assessment of adequacy as outlined in the "Overall remarks, attachments" section and in the attached QPRF. - Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs and grouping of chemicals (R.6)
- Principles of method if other than guideline:
- QSAR mass based toxic unit additivity, see attached QMRF for details
- GLP compliance:
- no
- Test organisms (species):
- Pimephales promelas
- Test type:
- other: (Q)SAR
- Water media type:
- freshwater
- Total exposure duration:
- 28 d
- Reference substance (positive control):
- not required
- Duration:
- 28 d
- Dose descriptor:
- EC10
- Effect conc.:
- 1.086 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
Reference
Description of key information
EC10 (28 d): 1.086 mg/L (C/EO QSAR mass based toxic unit additivity)
Key value for chemical safety assessment
Additional information
Studies on the chronic toxicity of the 'mixed branched/linear' subgroup of the AE category are currently ongoing. Therefore, the endpoint of chronic toxicity to fish will be re-evaluated as soon as all experimental data are available.
The effect concentrations used for the assessment of the chronic toxicity to fish were derived by AE substance specific QSAR calculations. The model was developed based on literature data (Wind & Belanger, 2006; Boeije et al., 2006; Belanger et al, 2006).
For the assessment of chronic toxicity of the target substance to fish an EC10 (28 d) of 1.086 mg/L was predicted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.