Registration Dossier
Registration Dossier
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EC number: 428-420-3 | CAS number: 71119-22-7 MOPS-NA
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not specified
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.1
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium 3-morpholin-4-ylpropane-1-sulfonate
- EC Number:
- 428-420-3
- EC Name:
- Sodium 3-morpholin-4-ylpropane-1-sulfonate
- Cas Number:
- 71119-22-7
- Molecular formula:
- C7H14NNaO4S
- IUPAC Name:
- sodium 3-(morpholin-4-yl)propane-1-sulfonate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No further information provided in SNIF.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Remarks:
- distilled
- Details on oral exposure:
- No further information provided in SNIF.
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- No further information provided in SNIF.
- Statistics:
- No information provided in SNIF.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: Pilo-erection and/ or hunched posture were observed in 8 animals 4 h after treatment. No other signs of systemic toxicity were noted during the study.
- Gross pathology:
- No macroscopic abnormalities were recorded after necropsy of all animals at the end of the study.
- Other findings:
- No further information provided in SNIF.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was determined to be > 2000 mg/kg bw in male and female rats after oral treatment with the test item.
- Executive summary:
In an acute oral toxicity study conduced using the standard acute methods each five male and female rats were treated with the test item. All animals received 2000 mg/kg bw of the test item. No mortality was observed.Pilo-erection and/ or hunched posture were observed in 8 animals 4 h after treatment. No other signs of systemic toxicity were noted during the study.No macroscopic abnormalities were recorded after necropsy of all animals at the end of the study. Based on these observations the LD50 was determined to be higher than 2000 mg/kg bw in rats.
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