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EC number: 208-591-9 | CAS number: 534-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-03-18 to 2008-04-22
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.11 (Mutagenicity - In Vivo Mammalian Bone-Marrow Chromosome Aberration Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.5380 (In Vivo Mammalian Cytogenetics Tests: Spermatogonial Chromosomal Aberrations)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Caesium carbonate
- EC Number:
- 208-591-9
- EC Name:
- Caesium carbonate
- Cas Number:
- 534-17-8
- Molecular formula:
- CCs2O3
- IUPAC Name:
- caesium carbonate
- Reference substance name:
- Cesiumcarbonate technical grade
- IUPAC Name:
- Cesiumcarbonate technical grade
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Wistar Hanlbm: WIST (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann GmbH, D-33178 Borchen
- Age at study initiation:6 - 10 weeks
- Weight at study initiation: males 163.4 +- 8.6 g; females: 153.1 +- 6.0 g
- Assigned to test groups randomly: [no/yes, under following basis: ] yes
- Fasting period before study:
- Housing: single, Makrolon Type II with wire mesh top granulated soft wood bedding
- Diet (e.g. ad libitum): pelleted standard diet ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +- 3°C
- Humidity (%): 30 - 70%
- Photoperiod (hrs dark / hrs light): artificial light 6.00 a.m. - 6.00 p.m.
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- deionised water
- Details on exposure:
- As estimated by a pre-experiment 1750 mg/kg b.w. was suitable as the high dose ( toxic reactions like reduction of spontaneours activity, tremor apathy) .
- Duration of treatment / exposure:
- - 24h and 48 h (only the high dose group)
- Frequency of treatment:
- Single application
- Post exposure period:
- None
Doses / concentrations
- Remarks:
- Doses / Concentrations:
437.5, 875 and 1750 mg/kg b.w.
Basis:
actual ingested
- No. of animals per sex per dose:
- 5 animals per sex per test group
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- CPA; Cyclophosphamide
- Route of administration: orally, once
- Doses / concentrations: 15 mg/kg (Volume administered 10 ml/kg b.w.)
- Solution prepared on day of administration
Examinations
- Tissues and cell types examined:
- Bone marrow.
- Details of tissue and slide preparation:
- The marrow was flushed out with 5 ml hypotonic potassium chloride solution and incubated for 20 min at 37°C. The cells were sedimented, the supernatant was discarded and the cell pellet was fixed (60 min). The cell pellet was gently resuspended to make a relatively thin cell suspension. Suspension was spread by flame-drying. One slide was made from each bone marrow sample.
- Evaluation criteria:
- - positive control with statistical response
- vehicle control with aberration rate < 2 %
- dose-related increase in the number of chromosomal aberrations and reproducible statistically significant positive response is classified as mutagenic - Statistics:
- The statistical evaluation of appropriate data was performed with non-parametric Mann-Whithey test.
Results and discussion
Test results
- Key result
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Cesium carbonate did not induce chromosome mutations as determined by the chromosome aberration test with bone marrow cells of the rat in vivo.
- Executive summary:
The study was performed to investigate the potential of Cesium carbonate to induce chromosome aberrations in bone marrow cells of the rat according to OECD Guideline 475 (1997) and US EPA OPPTS 870.5385. The test item was formulated in deionised water. The volume administered orally was 10 mL/kg b.w. Rats were treated once with 437.5 mg/kg or 875 mg/kg or 1750 mg/kg. After 24 h and 48h (only the high dose group) spindle inhibitor colcemide was injected intraperitoneal, bone marrow cells were collected for chromosome aberration analysis and 10 animals (5 males/5 females) per test group were evaluated for occurrence of cytogenetic demage. No relevant reduction of mitotic indices could be observed. Therefore Test item was not cytotoxic in the bone marrow. No statistically significant increase in the frequency of aberrant cells occurred. Results are comparable to vehicle control. In addition positive control showed a significant increase of induced aberration frequency. Systemic bioavailability after oral administration was shown in an additional study investigating the plasma levels of the test item in male rats (IUCLID section 7.1.1).
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