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EC number: 260-375-3 | CAS number: 56773-42-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Several acute toxicity studies were performed with tetraethylammonium heptadecafluorooctanesulphonate .
In the key study for acute oral toxicity a LD50 = 190 mg/kg bw (rat, male) was found. In another study in rats a LD50 = 632 mg/kg bw (female rats); LD50 > 200 mg/kg bw (male rats) was determined. In a not assignable study (secondary literature) in rats acute oral LD50 values and 95% confidence limits were calculated for male rats (233 [160-339] mg/kg), females (271 [200-369] mg/kg) and combined male and female rats (251 [199-318] mg/kg).
Acute inhalative toxicity was tested with the test substance in male rats, mice, hamsters, rabbits. Rats and mic were exposed whole body for 1 hours at room temperature to a concentration of 1368 and 9337 mg/m³; hamster and rabbits were exposed whole body for 1 hours at room temperature to a concentration of 1375 and 9087 mg/m³ of the test substance in an 400 l inhalation chamber. Mortality and clinical signs were recorded during a post-expsoure period of 7 days. Rats and mic were exposed whole body for 4 hours at room temperature to a concentration of 1585, 1575 or 11612 mg/m³; hamster and rabbits were exposed whole body for 4 hours at room temperature to a concentration of 1730 or 10325 mg/m³ of the test substance in an 400 l inhalation chamber. Mortality and clinical signs were recorded during a post-expsoure period of 7 days. In both studies no mortality was observed. In a not assignable study (secondary literature) PFOS dust was administered whole body for 4 h in air to Sprague-Dawley rats, 5/sex/group, levels of 1.89 to 45.97 mg/l PFOS to eight test groups. An LC50 = 5.2 (4.4 – 6.4) mg/l was determined.
a valid study for dermal toxicity determined a LD50 > 2000 mg/kg bw. At 2000 mg/kg bw one out of 10 animals died.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 200 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 1 000 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
From the acute oral toxicity studies a LD50 > 200 mg/kg bw for male and female rats is assumed on a weight of evidence consideration.
In 2 studies on rats, mice, hamster and rabbits with whole body exposure for 1 and 4 hours no mortality was observed. In the 1 hour study a LC50 > 9337 mg/m³ (male rat + mouse), LC50 > 9087 mg/m³ (male hamster + rabbit) was determined. In the 4 hours study a LC50 > 11612 mg/m³ (male rat + mouse), LC50 > 10325 mg/m³ (male hamster + rabbit) was determined. An additional study on rats for 1 hour revealed an LC50 = 5.2 mg/l (5200 mg/m³). Following Haber's rule a conversion of the 1 hour LC50 to a 4 hour LC50 and based on a weight of evidence consideration a LC50 > 1 mg/l (rat) for PFOS dust seems justified.
In a acute dermal toxicity study 5 male and 5 female rats were exposed semicoocusively to PFOS for 24 hours. One of the male rats died after 11 days. Liver and kidneys of the deceased animal were light discolored.
Justification for classification or non-classification
Based on the results of the oral toxicity studies a LD50 > 200 mg/kg bw a LC50 > 1 mg/l for acute inhalation toxicity seems reliable.
Therefore a classification as Xn; R20/22 (GHS: Acute Tox 4, H 332; Acute Tox 3, H 301) is justified. In an acute dermal toxicity study,
1 of 10 animals died at 2000 mg/kg bw. According to the OECD TG 434 for GHS a classification as Acute Tox 5, H313 (may be harmful in contact with skin). However, this classification for acute dermal toxicity has no relevance for EU countries, because under EU CLP category 5 is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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