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Diss Factsheets
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EC number: 298-265-2 | CAS number: 93783-70-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No bioaccumulation potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
According to the Annex VIII of the REACH Regulation (EC 1907/2006), the assessment of the toxicokinetics behaviour of the substance should be done to the extent that can be derived from the relevant available information.
Based on the physicochemical properties of the substance (mainly physical state and particle size, chemical structure and functional groups, molecular weight, water solubility, octanol/water partition coefficient), absorption is expected to occur mainly by oral route, while low absorption is expected by dermal route and by inhalation.
In particular, absorption, distribution and excretion of the substance are controlled by:
1. nature of the substance, i.e. a salt
2. molecular weight of the 2 ions well below 500 a.u.,
3. higher affinity to aqueous phase than to organic phase with log Pow of -0.3993 at 20 °C,
4. particle size distribution with less than 2 % volume of particles below 4 µm size, less than 8 % volume of particles below 10 µm and ca. 100 % volume of particles below 100 µm
5. high water solubility, i.e. ca. 25.22 mg/l at 20 °C.
As for the potential of bioaccumulation, it is expected to be low, based on log Pow far below the threshold value of 4 for bioaccumulation.
Once entered the body, molecules may undergo cleavage of the diazo bond as well as dealkylation of the amines. Such process are expected to enhance water solubility and, consequently, rate of excretion of the substance.
Excretion of both substance and metabolites mainly occur in faeces and urine.
In available toxicological studies by oral route, treatment related mortality was recorded in an acute toxicity study, leading to a LD50 between 50 and 300 mg/kg; severe toxic effects at the dose of 80 mg/kg were seen in a preliminary teratogenicity assay in dams, but no teratogenic evidences were seen. In a repeated dose toxicity study, reversible effects on liver and kidney were recorded at the dose of 40 mg/kg; in a reproductive/developmental toxicity study at doses up to 15 mg/kg, no toxic effect was recorded.
Overall, such findings proved absorption of the substance by oral route and effects of the substance itself and/or of its metabolites.
Low absorption rate by dermal route was expected based on the hydrophilicity along with the presence of a heterocyclic ammonium ion in the chemical structure. Furthermore, low absorption was confirmed by the lack of toxic effects upon acute exposure by dermal route at dose of 2000 mg/kg, compared to the remarkable toxicity upon acute oral exposure.
No studies via inhalation were conducted. However, absorption by this exposure route was expected to be negligible based on the particle size distribution of test substance along with its hydrophilic character, that limit exposure of alveolar region as well as absorption across the epithelium. As for particles in the upper respiratory tract, mainly dissolved in mucus, either clearance from the body or swallowing was expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.