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EC number: 605-539-0 | CAS number: 169115-74-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: other: gene mutation and small chromosomal deletions
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program
- Author:
- Foureman P
- Year:
- 1 994
- Bibliographic source:
- Env Mol Mutagen 23, 51-63
Materials and methods
- Principles of method if other than guideline:
- standard procedure as described in detail by Woodruff et al., Env. Mutagen. 6, 189-202, 1984 and others:
Adult Canton-S males were subjected to a 3 day feeding exposure. They were mated to Basc females using a 2 to 3 day brooding pattern for a total of three broods spanning 7 days. If the feeding SLRL test were negative, an injection exposure was performed. As in the feeding exposure, a 2 to 3 day brooding pattern for three broods was used. - GLP compliance:
- not specified
- Type of assay:
- Drosophila SLRL assay
Test material
- Reference substance name:
- 1-aminopropan-2-ol
- EC Number:
- 201-162-7
- EC Name:
- 1-aminopropan-2-ol
- Cas Number:
- 78-96-6
- IUPAC Name:
- 1-aminopropan-2-ol
- Reference substance name:
- 1-amino-2-propanol
- IUPAC Name:
- 1-amino-2-propanol
- Details on test material:
- - Name of test material (as cited in study report): Mono-isopropanolamin
- Analytical purity: 96.4 %
Constituent 1
Constituent 2
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- other: Canton S
- Sex:
- male
Administration / exposure
- Route of administration:
- other: oral feed; if the compound failed to induce mutations, injection exposure was used
- Vehicle:
- for injection: distilled water
- Details on exposure:
- exposure levels were chosen based on solubility, palatability, and toxicity of the chemical. In range-finding studies, an attempt was made to find a concentration resultin in approximately 30% mortality after 72 h of feeding or 24 h after injection. The maximum concentration for feeding and injection was arbitrarily set to 50.000 ppm.
- Duration of treatment / exposure:
- feeding study: 3 days; If the results of the feeding SLRL test were negative, a single injection exposure was performed
- Frequency of treatment:
- continuously in feed
Doses / concentrations
- Remarks:
- Doses / Concentrations:
feeding study: 24000 ppm, injection: 1900 ppm
Basis:
- No. of animals per sex per dose:
- no data; a minium of 5000 chromosomes were scored in each of the treated and concurrent control groups, unless the mutant frequency exceeded 1%.
- Control animals:
- yes, concurrent no treatment
Examinations
- Evaluation criteria:
- A minimum of approximately 5,000 chromosomes were scored in each of the treated and concurrent control groups, unless the mutant frequency exceeded 1%. Clusters were identified using the Poisson distribution (Owen, 1962) and were removed before analysis.
- Statistics:
- The statistical evaluation of a SLRL test included a comparison with the concurrent solvent control using the normal approximation to the binomial distribution, as presented by Margolin et al. (1983), as well as a comparison with the historical control as described by Mason et al. (1992). In order to be considered mutagenic, the mutant frequency in the treated sample must exceed 0.15% with a P value of less than 0.05, or the treated frequency must exceed 0.1% with a P value of less than 0.01. If the treated frequency was between 0.1% and 0.15% and the P value was between 0.1 and 0.01; or if the treated frequency was higher than 0.15%, and the P value was between 0.1 and 0.05 the assay was considered equivocal. All other assays were considered negative.
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- In range-finding studies, an attempt was made to find a concentration resultin in approximately 30% mortality after 72 h of feeding or 24 h after injection. The maximum concentration for feeding and injection was arbitrarily set to 50.000 ppm.
- Vehicle controls validity:
- valid
Any other information on results incl. tables
Dose (ppm) |
Route |
Mortality (%) |
Sterility (%) |
Lethals |
Tests |
Total lethals |
Total tests |
Lethals (%) |
||||
Br1 |
Br2 |
Br3 |
Br1 |
Br2 |
Br3 |
|||||||
24000 |
feeding |
5 |
17 |
1 |
0 |
2 |
2658 |
1421 |
847 |
3 |
4926 |
0.06 |
0 |
|
|
|
1 |
0 |
1 |
2875 |
2748 |
2414 |
2 |
8037 |
0.02 |
1900 |
injection |
14 |
8 |
2 |
2 |
2 |
1911 |
1675 |
1562 |
6 |
5148 |
0.12 |
0 |
|
|
|
0 |
2 |
0 |
1739 |
1493 |
1079 |
2 |
4311 |
0.05 |
one cluster of 3 in the injection control and one of 4 in the treated feeding experiment
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
- Executive summary:
Isopropanolamine was tested for mutagenic activity in germ cells of male Drosophila melanogaster using the sex linked recesssive lethal (SLRL) assay. After 3 days oral exposure via feed with 24000 ppm isopropanolamine followed by a 2 -3 day brooding pattern for a total of 3 broods spanning 7 days the test item was judged as non-mutagenic. This result was verified by a second experiment with injection exposure to 1900 ppm isopropanolamine. The test item was judged negative in the Drosophila SLRL assay.
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