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EC number: 268-952-1 | CAS number: 68155-26-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The intermediate called PRODUCT L6143 is mainly composed of Amides, vegetable oil, N, N-bis(hydroxyethyl) at ca 86%. This component cannot be well defined on chain lenghts, number of insaturations and types of fatty acids. In fact, the term "vegetable oil" is used to describe this main component. To understand the environmental behaviour of the intermediate PRODUCT L6143, this major component can be taken in to account, but no data are available, with the exemption of similar substances with a defined number of carbons and insaturations:
Amides, C8-18 (even numbered) and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68155-07-7
Amides, C12-18 (even-numbered) and C18 (unsatd.), N,N-bis(hydroxyethyl), CAS 90622-74-5
Amides, C16-18 and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68603-38-3
Amides, soya, N,N-bis(hydroxyethyl),CAS 68603-38-3
Phototransformation in air
Data on phototransformation in air are estimated by AOP Win v1.92, using default values of hydroxyl radical concentration and hydroxyl rate constant; the accuracy of this method is well described by predicting available experimental values; due to lack of complete training set, no precise applicability domain for this methodology is possible.
The first similar substance, Amides, C8-18 (even numbered) and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68155-07-7, SMILES CCCCCCCC(=O)N(CCO)CCO has an
OVERALL OH Rate Constant = 43.6393 E-12 cm3/molecule-sec and and
HALF-LIFE of 0.245 Days (12-hr day; 1.5E6 OH/cm3).1 2
The second, Amides, C12-18 (even-numbered) and C18 (unsatd.), N,N-bis(hydroxyethyl), CAS 90622-74-5, SMILES CCCCCCCCC=CCCCCCCCC(=O)N(CCO)CCO present two isomers:
OVERALL OH Rate Constant = 110.8153 E-12 cm3/molecule-sec (Cis-isomer)
OVERALL OH Rate Constant = 118.4153 E-12 cm3/molecule-sec (Trans-isomer)
Half-Life = 1.158 Hrs (12-hr day; 1.5E6 OH/cm3) (Cis-isomer)
Half-Life = 1.084 Hrs (12-hr day; 1.5E6 OH/cm3) (Trans-isomer).
The calculation program AOP Win v1.92 indicates that reaction with nitrate radicals may be important.1 3
The Amides, C16-18 and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68603-38-3, SMILES CCCCCCC=CCCCCCCC=CCCN(CCO)CCO has an
OVERALL OH Rate Constant = 234.9765 E-12cm3/molecule-sec and and anHalf-Life of 0.546 hours.1 4
References:
1AOP Win v1.92 (EPI Suite v.4.00 by EPA);
2ECHA Registration Dossier, Amides, C8-18 (even numbered) and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68155-07-7;
3ECHA Registration Dossier, Amides, C12-18 (even-numbered) and C18 (unsatd.), N,N-bis(hydroxyethyl), CAS 90622-74-5;
4ECHA Registration Dossier, Amides, C16-18 and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68603-38-3.
Hydrolysis
No data, estimation data nor calculation data on hydrolysys on similar substances of the main component are available.
It is no possible to conclude if the PRODUCTL6143 can be hydrolysed at environmental conditions.
Biodegradability
In an experimental ready biodegradability CO2 Evolution Test (OECD Guideline 301 B) Amides, C8-18 (even numbered) and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68155-07-7 is resulted readily biodegradable after 28 days, and the same result on biodegradability was found in a manometric respirometry test (EU Method C.4-D), except that in this case it failed the 10-day window, condition not applicable to UVCB substance.
In an ready biodegradability Closed Bottle Test (OECD Guideline 301 D), amides, C12-18 (even-numbered) and C18 (unsatd), N,N-bis(hydroxyethyl) is considered to be readily biodegradable under the test condictions (84 % at 2 mg/L and 71 % at 5 mg/L).2
Amides, C16-18 and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68603-38-3 is considered ready biodegradable, after 28 days, under the test condition of an OECD 301D (closed bottle) test. This amide was also exposed to the activated domestic sewage sludge according to the OECD 301B.
The test substance attained 62% degradation after 28 days but did not meet the 10-d window validation criterion.
The prediction usingBIOWIN v 4.10 indicates a readily biodegradability for all these substances.4
Amides, soya, N,N-bis(hydroxyethyl),CAS 68603-38-3 was also tested according to the Coupled Units test, as described in Directive 87/302/EEC. It was considered to be ultimately biodegradable.
A conclusion, biodegradability of PRODUCTL6143 can be drawn based on the main component similar substances, and therefore the intermediate is considered to be ready biodegradable.
References:
1ECHA Registration Dossier, Amides, C8-18 (even numbered) and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68155-07-7;
2ECHA Registration Dossier, Amides, Amides, C12-18 (even-numbered) and C18 (unsatd.), N,N-bis(hydroxyethyl), CAS 90622-74-5;
3BIOWIN v4.10(EPI Suite v.4.00 by EPA)
4ECHA Registration Dossier, Amides, C16-18 and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68603-38-3.
Bioaccumulation
The bioaccumulation factors (BCF) of Amides, C8-18 and C18-unsatd., N,N-bis(hydroxyethyl) was estimated by BCFBAF v3.01. Estimated log Kow was used for the calculation. The BCF was found to be 3.16 L/kg wet-wt.1 2
The bioaccumulation potential of amides, C12-18 (even-numbered) and C18(unsatd.), N,N-bis(hydroxyethyl), was estimated to be 99.66 L/kgwet weight according to the BCFBAF v3.01 model of EPIWIN v.4.0, using an estimated log Kow.1 3
The bioaccumulation potential of amides, C16-18 (even-numbered) and C18-unsatd., N,N-bis(hydroxyethyl) was estimated to be 81 L/kg wet weight (log BCF = 1.9) according to the BCFBAF v3.01 model of EPIWEB v 4.1.1 4
As a conclusion, the PRODUCT L6143 is considered to be not bioaccumulative.
References:
1BCFBAF v3.01 (EPI Suite v.4.00 by EPA);
2ECHA Registration Dossier, Amides, C8-18 (even numbered) and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68155-07-7;
3ECHA Registration Dossier, Amides, Amides, C12-18(even-numbered) and C18(unsatd.), N,N-bis(hydroxyethyl), CAS 90622-74-5;
4ECHA Registration Dossier, Amides, C16-18 and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68603-38-3.
Adsorption /Desorption
The estimated weighted mean Koc for amides, C8-18 and C18-unsatd., N,N-bis(hydroxyethyl) using MCI approach of KOCWIN v2.00 program (EPIWEB v 4.0) was found:
Koc 10 L/kg (MCI method)
Koc 3.66 L/kg (Kow method).1 2
The estimated Koc for amides, C12-18 (even-numbered) and C18 (unsatd.),N,N-bis (hydroxyethyl), was found to be
Koc 1448 L/kg (MCI method)
Koc 1457 L/kg (Kow method).1 3
The estimated Koc for amides, C16-18 (even-numbered) and C18 (unsatd.),N,N-bis (hydroxyethyl), was found to be
Koc 5778 L/kg (MCI method)
Koc 3872 L/kg (Kow method).1 4
According to Level III Fugacity Model the mass amount in soil is more than 70% for all these amides (C8-18 and C12-18).5
As a conclusion, the PRODUCT L6143 is expected to partition primarily to soil.
References:
1KOCWIN v2.00 (EPI Suite v.4.00 by EPA);
2ECHA Registration Dossier, Amides, C8-18 (even numbered) and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68155-07-7;
3ECHA Registration Dossier, Amides, C12-18 (even-numbered) and C18 (unsatd.), N,N-bis(hydroxyethyl), CAS 90622-74-5;
4ECHA Registration Dossier, Amides, C16-18 and C18-unsatd., N,N-bis(hydroxyethyl), CAS 68603-38-3.
5Level III Fugacity Model(EPI Suite v.4.00 by EPA).
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