Registration Dossier
Registration Dossier
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EC number: 617-435-2 | CAS number: 83066-88-0
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only very little information is available. The information is based on an internal memorandum with a short summary of the results of a study report. The full study report is not available.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- (RS)-2-[4-(5-Trifluoromethyl-2-pyridyloxy)phenoxy]propionic
- EC Number:
- 614-949-9
- Cas Number:
- 69335-91-7
- Molecular formula:
- C15H12F3NO4
- IUPAC Name:
- (RS)-2-[4-(5-Trifluoromethyl-2-pyridyloxy)phenoxy]propionic
- Reference substance name:
- 2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid
- IUPAC Name:
- 2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid
- Details on test material:
- The test substance is the racemate 2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS# 69335-91-7). It is a 1:1 mixture of the two enantiomers (2R)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS# 83066-88-0; the substance defined in section 1) and (2S)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS# 95977-30-3).
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 30 days
- Frequency of treatment:
- not applicable (repeated dietary administration)
Doses / concentrationsopen allclose all
- Dose / conc.:
- 50 ppm
- Remarks:
- Basis:
no data
- Dose / conc.:
- 500 ppm
- Remarks:
- Basis:
no data
- No. of animals per sex per dose:
- no data
Results and discussion
Results of examinations
- Details on results:
- Repeated dietary administration for 30 days to rats produced significant liver enlargement in male rats fed 50 ppm or 500 ppm and slight liver damage (cloudy swelling and or hypertropy of hepatocytes) at 500 ppm. No effects were seen in female rats at these doses. All feed concentrations refer top the test substance (i.e. the racemate).
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Full information as given in the memorandum:
Repeated dietary administration for 30 days to rats produced significant liver enlargement in male rats fed 50 ppm or 500 ppm and slight liver damage (cloudy swelling and or hypertrophy of hepatocytes) at 500 ppm. No effects were seen in female rats at these doses.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
