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EC number: 233-802-6 | CAS number: 10361-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1991-01-29 to 1991-02-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Code of Federal Regulations 16: 1500.3
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Yttrium trinitrate
- EC Number:
- 233-802-6
- EC Name:
- Yttrium trinitrate
- Cas Number:
- 10361-93-0
- Molecular formula:
- N3O9Y
- IUPAC Name:
- yttrium trinitrate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): Yttrium nitrate
- Substance type: Off-white crystalline/powdered solid
- Physical state: Solid
- Further information on test material confidential.
Constituent 1
- Specific details on test material used for the study:
- The sample was tested as a 50% w/w solution in distilled water. The gravity of the test material was 1.406 (dosage of 1.25 g/kg), 1.382 (dosage of 2.5 g/kg) and 1.354 (dosage of 5.0 g/kg).
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hilltop Lab Animals, Scottdale, PA, USA
- Age at study initiation: no data
- Weight at study initiation: male: 208-225 g; female: 202-221 g
- Fasting period before study: approximately 18 hours prior to selection and test initiation
- Housing: individually in suspended stainless steel caging with mesh floors
- Diet (e.g. ad libitum): pelleted purina rat chow ad libitum from 1 h after dosing
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: 5, 6 or 12 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.9 to 22.2°C
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- distilled water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: The sample was tested as a 50% w/w solution in distilled water.
- Dosing volumes: 1.78 mL/kg (1250 mg/kg); 3.62 mL/kg (2500 mg/kg); 7.43 mL/kg (5000 mg/kg) - Doses:
- 1250, 2500 and 5000 mg/kg
Data for the highest dose came from a limit test. - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The rats were observed at approximately 1, 2 and 4 hours after dosing and at least once daily thereafter for signs of gross toxicity and mortality. Body weights were recorded initially, at termination (day 14) or after death.
- Necropsy of survivors performed: Yes, necropsies were performed on all decedents. - Statistics:
- The LD50 was calculated by the Litchfield-Wilcoxon Method of Probit Analysis or estimated graphically.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 650 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 240 - 2 190
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 570 - 2 540
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: estimated graphically
- Mortality:
- 1250 mg/kg: 20% mortality occurred by day 2
2500 mg/kg: 90% mortality occurred by day 2
5000 mg/kg: 100% mortality occurred by day 3 - Clinical signs:
- other: 1250 mg/kg: Following test material administration, all animals appeared lethargic and had a hunched posture. All surviving animals recovered from the above toxic signs by day 3. 2500 mg/kg: Following test material administration, all animals appeared let
- Gross pathology:
- 1250 mg/kg: Necropsy of the decedents revealed distention of the stomach with discoloration of the pyloric region and intestines.
2500 mg/kg: Necropsy of the decedents revealed distention of the stomach, with discoloration of the pyloric region and intestines.
5000 mg/kg: Necropsy of the decedents revealed distention of the stomach with a cloudy white fluid and discoloration of the intestines. The two animals which died after day 1 also exhibited discoloration of the lungs and liver. - Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 calculated by Probit analysis was 1650 mg/kg with 95% confidence limits of 1240 to 2190 mg/kg for male and female animals. Therefore the substance is considered classified as category 4 (H302) according to the criteria of the CLP Regulation.
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