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EC number: 939-409-2 | CAS number: 1329-99-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.3 mg/L
Additional information
For the endpoint short-term toxicity to fish two studies are available: one Klimisch 1 key study and a supporting Klimisch 2 study. For the risk assessment the result from the more conservative Klimisch 1 study was used.
in the GLP Klimisch 1 study from Zok (1997) the toxicity of Depanol I to zebra fish was determined according to EU test guideline C.1 and OEC 203. The test was performed in two parts, first the concentrations from 10, 22, 50 and 100 mg/L and then from 1, 2.2, and 5 mg/L since there was 100 % mortality at 10 mg/L. At nominal 5 mg/L there was no mortality after 96 hours. Hence, the highest concentration without mortality was nominal 5 mg/L, corresponding to a measured concentration of 0.7 mg/L. Since the measured concentrations were significantly lower than the nominal, all values were based on mean measured concentrations. The 96 -hour LC50 was 1.3 mg/L and the 96 -hour LC100 was 2.4 mg/L. The discrepancy between nominal and mean measured concentrations is considered to be acceptable since the measured concentrations were used for the calculation of the endpoints. Therefore, the results of this study are considered relevant and acceptable for the risk assessment.
in the supporting GLP Klimisch 2 study from Markert and Jung (1988) the toxicity of Depanol J to zebra fish was determined according to EU test guideline C.1 and OEC 203. The test was performed in four parts, first the concentrations of 125 and 250 mg/L then 10 mg/, then 35 and 50 mg/L and at last 18 and 25 mg/L. Dose-verification analysis was not performed. In all treatment groups relevant for the determination of the LC50, the test item was reported to be in solution. At 18 mg/L a slight turbidity was observed after 48 hours. At 125 and 250 mg/L test item was floating on the surface of the test solutions. At nominal 10 mg/L there was no mortality after 96 hours. Hence, the highest concentration without mortality was nominal 10 mg/L. The 96 -hour LC50 was 27.6 mg/L and the 96 -hour LC100 was 50 mg/L. The endpoints were based on nominal concentrations. Due to the lack of dose-verification analysis, the exposure concentrations are not clear. Therefore, the results of this study are considered to have minor relevance for the risk assessment.
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