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EC number: 211-059-9 | CAS number: 628-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance (2-chloroethoxy)ethanol was found to be slightly irritating to skin and moderately irritating to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3
- GLP compliance:
- no
- Species:
- rabbit
- Type of coverage:
- other: Open;no data
- Controls:
- not specified
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 1.07
- Reversibility:
- no data
- Remarks on result:
- other: Slightly irritating
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- By primary dermal irritation index (PDII) from QSAR, skin irritation score of 2-(2-chloroethoxy)ethanol was estimated as 1.07.Based on this score 2-(2-chloroethoxy)ethanol was found to be slightly irritating to the rabbit skin
- Executive summary:
By primary dermal irritation index (PDII) from QSAR, skin irritation score of 2-(2-chloroethoxy)ethanol was estimated as 1.07. Based on this score 2-(2-chloroethoxy)ethanol was found to be slightly irritating to the rabbit skin and thus we be considered for skin irritation in category 2.
Reference
The prediction was based on dataset comprised from the following descriptors: "Primary Irritation Index"
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((("a" and "b" ) and ("c" and ( not "d") ) ) and ("e" and "f" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Similarity boundary:Target: C(Cl)COCCO
Threshold=60%,
Dice(Atom pairs)
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as No alert found by Protein binding by OASIS
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as alpha,beta-carbonyl compounds with polarized double bonds OR MA: Michael addition on conjugated systems with electron withdrawing group OR Mechanistic Domain: Michael addition by Protein binding by OASIS
Domain logical expression index: "e"
Parametric boundary:The target chemical should have a value of log Kow which is >= -0.908
Domain logical expression index: "f"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.568
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: estimation data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: unspecified
- Vehicle:
- unchanged (no vehicle)
- Irritation parameter:
- other: MMAS(modified maximum average score (MMAS))
- Basis:
- mean
- Max. score:
- 27
- Reversibility:
- not reversible
- Remarks on result:
- other: Slightly irritant to eye
- Interpretation of results:
- Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- By MMAS(modified maximum average score (MMAS)) from QSAR, eye irritation score of 2-(2-chloroethoxy)ethanolwas estimated as 27. Based on this score 2-(2-chloroethoxy)ethanol was found to be irritating to the eye of rabbit.
- Executive summary:
By MMAS(modified maximum average score (MMAS)) from QSAR, eye irritation score of 2-(2-chloroethoxy) ethanol was estimated as 27. Based on this score 2-(2-chloroethoxy)ethanol was found to be irritating to the eye of rabbit. Since the MMAS value is more than 25 so we cannot classify the substance as slightly irritating to eye and thus will have to place the substance to next level of classification in irritation category which as per the regulation is eye irritant in category 2 level.
Reference
The prediction was based on dataset comprised from the following descriptors: MMAS
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= -0.623
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.454
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation :
By primary dermal irritation index (PDII) from QSAR, skin irritation score of 2-(2-chloroethoxy)ethanol was estimated as 1.07.Based on this score 2-(2-chloroethoxy)ethanol was found to be slightly irritating to the rabbit skin. The irritation effect has also been supported by other studies from SAX and RTECS database which also indicate irritation effect on skin. The read across substance, which has 90% similarity also indicates irritation effect on skin.
Eye Irritation :
By MMAS(modified maximum average score (MMAS)) from QSAR, eye irritation score of 2-(2-chloroethoxy) ethanol was estimated as 27. Based on this score 2-(2-chloroethoxy)ethanol was found to be irritating to the eye of rabbit. Since the MMAS value is more than 25 so we cannot classify the substance as slightly irritating to eye and thus will have to place the substance to next level of classification in irritation category which as per the regulation is eye irritant in category 2 level.
Justification for selection of skin irritation / corrosion endpoint:
By primary dermal irritation index (PDII) from QSAR, skin irritation score of 2-(2-chloroethoxy)ethanol was estimated as 1.07.Based on this score 2-(2-chloroethoxy)ethanol was found to be slightly irritating to the rabbit skin
Justification for selection of eye irritation endpoint:
By MMAS(modified maximum average score (MMAS)) from QSAR, eye irritation score of 2-(2-chloroethoxy) ethanol was estimated as 27. Based on this score 2-(2-chloroethoxy)ethanol was found to be irritating to the eye of rabbit. Since the MMAS value is more than 25 so we cannot classify the substance as slightly irritating to eye and thus will have to place the substance to next level of classification in irritation category which as per the regulation is eye irritant in category 2 level.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: moderately irritating
Justification for classification or non-classification
The available studies indicate that (2-chloroethoxy)ethanol is irritant to skin in category 2, according to CLP regulation. Regarding the eye irritation classification the irritation effect is moderate and so the substance will have the classification in category 2 as per the C & L regulation.
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