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EC number: 617-143-5 | CAS number: 80675-49-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an in vivo study according to the OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay), no skin sensitizing potential of the test substance was observed (BASF SE, 2009).
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitisation
In the available study conducted according to the OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay), the skin sensitizing potential of the test substance (TS) was assessed by treating groups of 5 female CBA/J mice with a 30 % w/w preparation of the test substance in propylene glycol or with the vehicle alone (the 30 % preparation was the maximum technically applicable concentration). Each test animal was applied with 25 μL per ear of the test substance preparation or vehicle to the dorsum of both ears for three consecutive days. 3 days after the last application the mice were injected intravenously with 20 μCi of [3]H-thymidine in 250 μL of sterile saline into a tail vein. About 5 hours thereafter, the mice were sacrificed and the auricular lymph nodes were removed. The weights of each animal pooled lymph nodes were determined. Lymph nodes were then pooled group wise and further evaluated by measuring their cellular content and [3]H-thymidine incorporation into the lymph node cells (indicators of cell proliferation). Moreover, a defined area with a diameter of 0.8 cm was punched out of the apical part of each ear, and, for each test group, the weight of the pooled punches was determined in order to obtain an indication of possible skin irritation.
The stimulation indices (SI; i.e. fold of change as compared to the vehicle control) for cell count, [3]H-thymidine incorporation, lymph node weight and ear weight are summarized below:
Test group
Treatment
Cell count SI
[3]H-thymidine incorporation SI
Lymph node weight SI
Ear weight SI
1
vehicle propylene glycol
1.00
1.00
1.00
1.00
2
30 % TS in propylene glycol
1.31
2.33
1.12
1.08
When applied as 30 % preparation in propylene glycol, the test substance did not induce a biologically relevant response in the auricular lymph node cell counts (SI = 1.31; cut off value: 1.5). Concomitantly, the increase of [3]H-thymidine incorporation into the cells (SI = 2.33) was not biologically relevant (no increase above the cut off stimulation index of 3). Furthermore, there was no relevant increase in lymph node weights.
The test-substance preparation caused some increase in ear weights indicating ear skin irritation. The ears of all animals showed a yellow discoloration on study days 1 and 2 and on the day of lymph node removal. No signs of systemic toxicity were noticed
Thus, it is concluded that the test substance does not show a skin sensitizing effect in the Murine Local Lymph Node Assay under the test conditions chosen.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. As a result the substance is not considered to be classified for sensitisation under Regulation (EC) No 1272/2008, as amended for the tenth time in Regulation (EU) No 2017/776.
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