Cardamom, ext.

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1975

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given, but considered sufficiently reliable for the purpose of hazard assessment

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1975

Materials and methods

Type of sensitisation studied:

skin

Study type:

other: case report and patch testing

Principles of method if other than guideline:

A 59 year-old man has worked as a confectioner for the last 40 years and for 20 years he has had dermatitis of the hands and lower arms. Cardamom was supplied as seeds which he ground manually and this procedure often provoked a transient acute rhinitis. Then he mixes the cardamom powder into the dough, working barehanded. The patient was patch tested with the cardamom powder (as is and 50 % petrolatum) and Cardamom oil (2 %), which were applied on the back for 48 h and read after 72 h. About 20 control persons were tested with the additional allergens.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Cardamom, ext.

EC Number:

288-922-1

EC Name:

Cardamom, ext.

Cas Number:

85940-32-5

Molecular formula:

Not applicable, UVCB

IUPAC Name:

1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane; 2-(4-methylcyclohex-3-en-1-yl)propan-2-yl acetate

Test material form:

not specified

Details on test material:

- Name of test material (as cited in study report): Cardamom oil

Method

Type of population:

occupational

Controls:

- 20 control persons were tested with the additional allergens

Route of administration:

dermal

Results and discussion

Results of examinations:

-Patient showed papulovesicular reactions to cardamom (both undiluted and in a concentration of 50 %) and Cardamom oil (2 %). Repeat testing 2 months later produced identical results.
- No reactions were observed in control persons.

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:

Under the test conditions, patch testing with Cardamom oil showed dermal reactions in man.

Executive summary:

A 59 year-old man has worked as a confectioner for the last 40 years and for 20 years he has had dermatitis of the hands and lower arms. Cardamom was supplied as seeds which he ground manually and this procedure often provoked a transient acute rhinitis. Then he mixes the cardamom powder into the dough, working barehanded. The patient was patch tested with the cardamom powder (as is and 50 % petrolatum) and Cardamom oil (2 %), which were applied on the back for 48 h and read after 72 h. About 20 control persons were tested with the additional allergens.

 

Patient showed papulovesicular reactions to cardamom (both undiluted and in a concentration of 50 %) and oil of cardamom (2 %). Repeat testing 2 months later produced identical results. No reactions were observed in control persons.

 

Under the test conditions, patch testing with Cardamom oil showed dermal reactions in man.