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EC number: 287-625-4 | CAS number: 85566-16-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral and dermal LD50 values for both structural analoques were greater than 2000mg/kg.
There was no mortality after inhalation of a saturated atmosphere of CAS 27458 -92 -0 for 8h.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See justification attached to IUCLID chapter 13.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 400 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See justification attached to IUCLID chapter 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- >= 0.3 mg/L air
- Exp. duration:
- 8 h
- Remarks on result:
- other: as determined from read-across, CAS 27458-92-0
- Interpretation of results:
- study cannot be used for classification
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 300 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See justification attached to IUCLID chapter 13.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 960 mg/kg bw
- Remarks on result:
- other: as determined from read-across CAS 27458-92-0
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 960 mg/kg bw
Additional information
ORAL TOXICITY
Oral acute toxicity in rats was determined for the two structural analogues, CAS numbers 27458 -92 -0 (BASFSE, 2002) and 10042-59 -8 (Monsanto Company, 1979).
A GLP-compliant acute oral toxicity study was performed with structural analogue CAS 27458-92-0. The test was executed according to OECD guideline 423 and was performed on male and female Wistar rats according to the acute toxic class method. The test substance, which was dissolved in olive oil Ph.Eur./DAB, was administered orally (gavage) in a dose of 2000 mg/kg. The observation period was 14 days. Clinical signs observed were piloerection after 5 hours of administration in the male rats. Body weights increased during the study period. No mortality occurred and during the macroscopic pathology no abnormalities were noted. The LD50 value for male/female was determined to be >2000 mg/kg bw.
Additionally, an acute oral toxicity study was performed with structural analogue CAS 10042 -59 -8. The methods used were comparable to current guideline requirements and scientifically valid (non-GLP). The test substance was administered orally to male and female Sprague-Dawley rats via an unspecified method in doses of 5010, 6310, 7940, 10000 mg/kg. The observation period was 14 days. Clinical signs that were observed include increasing weakness, ocular discharge, diarrhea and collapse. Weight loss occurred during the first 4 days in survivors. Gross pathology showed hemorrhagic lungs, liver discoloration, and acute gastrointestinal inflammation in the decedents. The LD50 for male/female was determined to be 5400.0 mg/kg bw.
INHALATION TOXICITY
An inhalation risk test was performed with structural analogue CAS 27458-92-0. The test was performed in principle as described in OECD test guideline 403, but it was conducted before the implementation of GLP and OECD Guidelines. Data is restricted to inhalation hazard test with in part limited reporting, although these tests are sufficient for a valid risk characterisation. In the test, 6 male and 6 female Wistar rats were exposed (nose/head only) to a saturated test substance atmosphere of 0.3 mg/L (nominal) for 8 h. The observation period lasted 7 days. No mortality or clinical signs were observed and no gross pathological findings were noted. The LC0 for male/female Wistar rats was determined to be > 0.3 mg/L.
DERMAL TOXICITY
Dermal acute toxicity in rats was determined for both structural analogues.
Acute dermal toxicity was determined for structural analogue CAS 27458 -92 -0, by a method closely akin to the one-day cuff method of Draize et al. (1944). In this method, groups of 4 male albino rabbits are exposed to the test substance. The fur was removed by clipping and the dose was retained beneath an impervious plastic film (i.e. occlusive). The animals were immobilized/exposed for 24 hours. Afterwards, the film was removed and the animals were observed for 14 days. No information on clinical signs was given. An LD50 value of 7.07 mL/kg bw (ca. 5960 mg/kg bw) was determined.
Also, an acute dermal toxicity was performed with structural analogue CAS 10042-59 -8, where a single dermal dose of 3160, 5010 and 7940 mg/kg bw was applied on the skin of male and female New Zealand Albino rabbits for 24 hours. One of the two high dose animals died on day 2. The observation period lasted 14 days. Clinical signs observed were increasing weakness, diarrhea and collapse. Also weight loss occurred in days 2 - 6. Gross pathlogy showed hemorrhagic areas of the lungs, liver and spleen discoloration, enlarged gall bladder, darkened kidneys, and gastrointestinal inflammation in the decendents. The LD50 for male and females was determined to be > 5010.0 mg/kg bw.
Justification for classification or non-classification
Based on the available information the substance does not need to be classified for acute oral, inhalation and dermal toxicity, as in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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