Registration Dossier
Registration Dossier
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EC number: 204-814-9 | CAS number: 126-96-5
Endpoint summary
Administrative data
Description of key information
Additional information
Determination of the aquatic toxicity data, was done according to the method of Toxic Unit Summation (TUS) published by Sprague (Sprague J.B.,1970).
The data used for estimation of the results for endpoints:
- short term toxicity to fish;
- short term toxicity to aquatic invertebrates,
- toxicity to aquatic algae and cyanobacteria
come from results obtained in experimental studies for Acetic acid and Sodium acetate. Each read across approach for Sodium diacetate, was obtained using TUS calculation method, and the data on Acetic acid and Sodium acetate.
According these results it can be concluded that values of Sodium diacetate for these endpoint situate the substance above the classification limites for aquatic toxicity (according to CLP regulation).
The result of toxicity to microorganisms was calculated applying a read across approach from the results for Sodium acetate, based on the molecular weights of both substances (the studies for Acetic acid and Sodium acetate were realized using different methods, and the TUS calculation could not be applied).
Bibliography:
1. Teuschler, L.K. & Hertzberg, R.C. (1995), “Current and future risk assessment guidelines, policy and methods development for chemical mixtures”, Toxicology, vol. 105, pp. 137-144,
2. Sprague, J.B. (1970), “Measurement of pollutant toxicity to fish. II. Utilizing and applying bioassay results”, Water Research, vol. 4, pp. 3-32,
3. Wilkinson, C.F., Christoph, G.R., Julien, E., Kelley, J.M., Kronenberg, J., McCarthy, J. & Reiss, R. (2000), “Assessing the risks of exposures to multiple chemicals with a common mechanism of toxicity: How to cumulate?”, Regulatory Toxicology and Pharmacology, vol. 31, pp. 30-43,
4. U.S. EPA. 2000, “Supplementary guidance for conducting health risk assessment of chemical mixtures”, EPA/630/R-00/002. Washington, DC:U.S. Environmental Protection Agency.
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