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EC number: 260-982-3 | CAS number: 57843-53-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from June 22, 1988 to July 6, 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- guideline test with GLP using N, N, N’, N’-Tetrakis (2-hydroxyethyl) hexanediamide which is used for read-across purpose, as structurally similar to N,N,N',N'-tetrakis(2-hydroxypropyl) adipamide. Thus, the study is used for read-across to avoid duplicate tests.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N,N,N',N'-tetrakis(2-hydroxypropyl)adipamide
- EC Number:
- 260-982-3
- EC Name:
- N,N,N',N'-tetrakis(2-hydroxypropyl)adipamide
- Cas Number:
- 57843-53-5
- Molecular formula:
- C18H36N2O6
- IUPAC Name:
- N,N,N',N'-tetrakis(2-hydroxypropyl)hexanediamide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals and Animal Husbandry:
Male and female New Zealand White rabbits were obtained from Hazleton Research Animals, Denver, PA. Upon arrival, all animals were examined for physical abnormalities, identified by uniquely numbered ear tags, and quarantined for approximately two weeks. The animals were individually housed in stainless steel cages suspended above absorbent-paper pan liners which were changed 3 times per week. All animal rooms were environmentally controlled with controls set to maintain a temperature of 65 F (18 °C) with a relative humidity range of 40 to 60%. Temperature and relative humidity were monitored 24 hr a day, and the light cycle was automatically controlled, 12 hr on and 12 hr off. All rabbits had free access to filtered tap water (via automatic watering) and were fed approximately 125 g/day of Purina Laboratory Rabbit Chow High Fiber Diet.
One day prior to being dosed, six male and six female rabbits were selected from a healthy stock population. At the time they were dosed, the animals were approximately 17 weeks old. The body weights ranged from 2231 to 2625 g for males and from 2270 to 2634 g for females.
Administration / exposure
- Vehicle:
- other: 0.85% saline
- No. of animals per sex per dose:
- 6 per sex per dose
- Control animals:
- not specified
- Details on study design:
- Experimental Design
Test Substance Dose Number of
Administered (g/kq) Animals
Monomer QM-552 PMN 5.0 6M/6F
Observations and Determinations
All animals were observed for mortality, signs of ill health, or reaction to treatment at 1, 2 and 4 hr after dosing and once daily thereafter for 14 days. Body weights were recorded on Day 0 (prior to dosing) and on Days 7 and 14. Surviving rabbits were killed on Day 14 and a gross examination of organs was performed in situ.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no mortalities.
- Clinical signs:
- other: see remarks:
- Gross pathology:
- Necropsy revealed no gross changes.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 (dermal, rabbits) in either sex is greater than 5000 mg/kg.bw.
- Executive summary:
The dermal toxicity of test substance was assessed by applying the test article to the clipped intact skin of six male and six female New Zealand White rabbits at a dose of 5.0 g/kg body weight. The application sites were covered with impervious cuffs for a period of 24 hr, after which the cuffs were removed and the sites were wiped with water-soaked paper towels. There were no mortalities or treatment-related clinical signs over the 14 -day observation period. Erythema appeared on the application sites on Day 1, and test substance adhered to application sites throughout the observation period. There were no treatment-related body-weight effects. Necropsy revealed no gross changes. The acute dermal LD50 in male and female rabbits was greater than 5.0 g/kg. According to CLP (Regulation EC No. 1272/2008), the test substance is not to be classified for acute dermal toxicity.
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