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Diss Factsheets
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EC number: 947-449-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- Analytical verification of concentration is not done
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 115
- Deviations:
- no
- Principles of method if other than guideline:
- Concentration (CMC) is used to specify the water solubility. The CMC has been determined with the tensiometer KRUSS KT 100, which consists in the measurement of the surface tension with of a platinic plate, whereby the surfactant solution is continuously diluted by means of bi-distillated water. As long as the surfactant molecules do not yet aggregate to micelles the concentration of non-aggregated surfactant molecules increases and the surface tension decreases. At concentration higher than the CMC the concentration of micelles increases, meanwhile the concentration of non-aggregated surfactant molecules and the surface tension remain more or less constant. Two regression lines are drawn through the points representing the surface tension as a function of the concentration: The first through descending part and the second one through the more or less constant part of the curve. The intersection of both regression lines defines the CMC.
- GLP compliance:
- not specified
- Type of method:
- other: Tensiometer Kruss Standard plate method
- Water solubility:
- 11.15 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 25 °C
- Remarks on result:
- other: Critical micelle concentration
- Key result
- Water solubility:
- 2.24 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 25 °C
- Remarks on result:
- other: Corrected value for dry matter
- Conclusions:
- Under the study conditions, the the CMC or water solubility of the test substance was determined to be 11.150 mg/L and the corrected water solubility for the water free test substance was calculated to be 2.24 mg/L at 25°C.
- Executive summary:
A study was conducted to determined the water solubility of the test substance, based on critical micelle concentration (CMC), similar to the OECD Guideline 115 and EU Method A.5. Under the study conditions, the the CMC or water solubility of the test substance was determined to be 11.150 mg/L and the corrected water solubility for the water free test substance was calculated to be 2.24 mg/L at 25°C (Dobbelstein, 2017).
Reference
Results: The intercept of the regression lines at stable surface tension and the line representing the lineal decrease of Surface tension is considered to represent the Critical Micelle Concentration (CMC).
The Critical Micelle Concentration is therefore estimated as 11.150 mg/L.
Concentration (mg/L) | avg Surface tesnion (mN/m) |
1000 | -- |
1000 | 22.39 |
870.958 | -- |
870.958 | 22.08 |
758.582 | -- |
758.582 | 22.00 |
660.69 | -- |
660.69 | 22.11 |
575.43 | -- |
575.43 | 22.37 |
501.19 | -- |
501.19 | 22.36 |
436.51 | -- |
436.51 | 22.24 |
380.187 | -- |
380.187 | 22.26 |
331.131 | -- |
331.131 | 22.41 |
288.4 | -- |
288.4 | 22.69 |
251.187 | -- |
251.187 | 22.98 |
218.778 | -- |
218.778 | 23.72 |
190.54 | -- |
190.54 | 24.42 |
165.95 | |
165.95 | 24.89 |
144.542 | -- |
144.542 | 25.69 |
125.89 | -- |
125.89 | 26.66 |
109.64 | -- |
109.64 | 27.76 |
95.4985 | -- |
95.4985 | 28.38 |
83.17 | -- |
83.17 | 27.54 |
72.44 | -- |
72.44 | 25.74 |
63.095 | -- |
63.095 | 26.29 |
54.95 | -- |
54.95 | 26.36 |
47.863 | -- |
47.863 | 25.96 |
41.6899 | -- |
41.6899 | 24.60 |
36.3 | -- |
36.3 | 26.11 |
31.622 | -- |
31.622 | 26.07 |
27.542 | -- |
27.542 | 25.52 |
23.988 | -- |
23.988 | 25.66 |
20.892 | -- |
20.892 | 25.82 |
18.196 | -- |
18.196 | 26.21 |
15.849 | -- |
15.849 | 26.75 |
13.8 | -- |
13.8 | 26.74 |
12.022 | -- |
12.022 | 28.43 |
10.471 | -- |
10.471 | 29.38 |
9.12 | -- |
9.12 | 32.05 |
7.94 | -- |
7.94 | 35.15 |
6.918 | -- |
6.918 | 38.56 |
6.0256 | -- |
6.0256 | 42.30 |
5.24 | -- |
5.24 | 45.56 |
4.5708 | -- |
4.5708 | 47.78 |
3.981 | -- |
3.981 | 49.33 |
3.46 | -- |
3.46 | 50.48 |
3.01 | -- |
3.01 | 51.17 |
2.6308 | -- |
2.6308 | 52.35 |
2.29 | -- |
2.29 | 53.35 |
1.99 | -- |
1.99 | 53.60 |
1.73 | -- |
1.73 | 54.78 |
1.5136 | - |
1.5136 | 55.80 |
1.31 | -- |
1.31 | 56.77 |
1.1481 | -- |
1.1481 | 57.05 |
1 | -- |
1 | 58.36 |
The test substance is having more than 70% of water in composition. Using the following equation (suggested by Dobbelstein, 2017) the water solubility of the test substance (dry matter) will be calculated.
Water solubility (WS) = measured WS * (1 -0.7995)
Calculated water solubility of the test substance without moisture content = 11.150 mg/L * (1 -0.7995)
= 11.150 mg/L* (0.2005) = 2.24 mg/L
Description of key information
The water solubility was determined based on critical micelle concentration evaluated according to a method similar to OECD Guideline 115 and EU Method A.5 (Dobbelstein, 2017).
Key value for chemical safety assessment
- Water solubility:
- 2.24 mg/L
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.