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EC number: 687-893-6 | CAS number: 1150560-54-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26th August 2018 to 7th September 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- other: MEP, P.R. China, the Guidelines for the Testing of Chemicals, Effects on Biotic Systems (the Second Edition), No. 203 "Fish Acute Toxicity Test". (2013.8)
- Qualifier:
- according to guideline
- Guideline:
- other: EC, DG Health and Consumer Protection: Residues: Guidance on analytical quality control & validation procedures for pesticide residue analysis in food & feed SANCO/1257/2013 19/11/13 rev 0
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
- EC Number:
- 687-893-6
- Cas Number:
- 1150560-54-5
- Molecular formula:
- C13H9F4IN2O2
- IUPAC Name:
- 1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
- Test material form:
- solid: particulate/powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- HPLC/UV
- Details on sampling:
- Analysis frequency: test and control in 0 and 48 hour fresh solution and 48 and 72 hour old solution
Test solutions
- Details on test solutions:
- Nominal Concentration: 100mg/L
A weight of 1.0004 and 1.0063g of test item was added to 10L of test water. The solution was stirred using a stirring rate of 400rpm for 24 hours. 5L of solution was filtrated with 0.45 μm membrane.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Zebra fish (Danio rerio) were propagated in the facility with the parents originating from Hangzhou Hunter Biotechnology Inc. . No sign of disease or large mortalities
Acclimatation: Fish held under test conditions
Temperature: 23 ± 2°C
Light: 12 hours light / 12 hours darkness
Body length: 2.0 - 2.2cm
Weight: 0.1923 - 0.2132g
Feeding: Fish were not fed during the period of the test.
Study design
- Test type:
- semi-static
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- 2, 4, 24, 48, 72 and 96 hours
Test conditions
- Hardness:
- 140mg/L (as CaCO3)
- Test temperature:
- 21.2 - 23.1 oC
- Dissolved oxygen:
- 74.6 - 96.2%
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1.295 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Results with reference substance (positive control):
- LC50: 359.06mg/L - 95% Confidence Limit (314.71 ~ 409.67 mg/L)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the measured concentration and test results, the 96 hour LC50 of Methyl Iodouracil to Zebra fish was > 1.295mg/L.
- Executive summary:
A fish acute toxicity study of Methyl Iodouracil was conducted with Zebra fish (Danio rerio) over a 96 h exposure period.
Based on the results of the preliminary test, the definitive test was carried out with a test item concentration of 100 mg/L (nominal concentration). A concurrent blank control was performed in parallel. The solution was filtrated with 0.45 μm membrane.
7 fish were used for the test and control group.
The test was performed with a semi-static water renewal system (solutions replaced every 48 hours). Dissolved oxygen, pH of the old and new media were measured daily during the 96 h exposure period. Temperature was monitored continuously by an automatic temperature monitoring sytem and recorded.
During the 96 h exposure period no death or visible toxicity signs were observed in either the control group and test group of 100mg/L.
During the test period, chemical analysis on test item concentration in test media by HPLC showed that for the test media of 100mg/L the mean measured concentrations of fresh solutiuon was 1.311mg/L and the mean measured concentrations of old solution was 1.280mg/L. The mean concentration was 1.295mg/L.
Based on the measured concentration and test results, the 96 hour LC50 of Methyl Iodouracil to Zebra fish was > 1.295mg/L.
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