Reaction mass of 3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9RS)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide and of 3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9SR)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide; isopyrazam

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

19 Oct 2012 to 26 Nov 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

2008

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Key result

Temp.:

25 °C

Vapour pressure:

0 Pa

Temp.:

20 °C

Vapour pressure:

0 Pa

Results

The sample solution concentrations and masses of transferred test item are shown in Table 1. The individual and mean experimental vapor pressure results are shown in Table 2.

Overall result: vapour pressure at 20.0 °C (293 K) equals 5.2 x 10-8 Pa

vapour pressure at 25.0 °C (298 K) equals 1.4 x 10-7 Pa

 

Validation

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0.2 to 10 mg/L. This was satisfactory with a correlation coefficient of 1.000 being obtained.

To confirm specificity of the analytical method, aliquots of a standard solution and a sample solution were analysed using a diode array detector (DAD) to record the ultraviolet spectrum of the analyte peak used for quantification. The spectrum generated was consistent between the standard and sample solution

 

Discussion

Calculation of the final reported vapor pressure values have been performed from unrounded values, whereas individual intermediate values, such as areas, concentrations and masses presented in the tables have been rounded for the purpose of report generation. Therefore, minor discrepancies may be obtained if attempting to repeat the calculation process using reported data values presented to a reduced number of significant figures.

The absence of any detectable concentration of test item in any trap 2 (the second trap in series for each flow rate) on analysis indicated complete condensation of the test item in the trap 1.

 

 

Table 1. Masses of test item condense

Temperature[°C]	Saturator Column Flow Rate [mL/min]	Concentration of Sample Solution [mg/L]	Mass of Test Item Vapourised [µg]
60	30	0.305	6.09
	40	0.387	7.74
	50	0.497	9.95
70	30	1.28	25.7
	40	1.68	33.6
	50	2.20	43.9
80	30	2.30	46.0
	40	3.00	60.1
	50	3.95	79.1

 

Table 2. Experimental vapour pressure values

Temperature[°C]	Saturator Column Flow Rate [mL/min]	Total Volume of Gas*[mL]	Mass of Test Item Vapourised [µg]	Vapour Pressure [Pa]	Mean Vapour Pressure [Pa]
60	30	7.42 x 10^5	6.09	6.3 x 10^-5	6.2 x 10^-5
	40	9.89 x 10^5	7.74	6.0 x 10^-5
	50	1.24 x 10^6	9.95	6.2 x 10^-5
70	30	7.53 x 10^6	25.7	2.7 x 10^-4	2.7 x 10^-4
	40	1.00 x 10^6	33.6	2.7 x 10^-4
	50	1.26 x 10^6	43.9	2.8 x 10^-4
80	30	2.50 x 10^5	46.0	1.2 x 10^-3	1.2 x 10^-3
	40	3.33 x 10^5	60.1	1.1 x 10^-3
	50	4.16 x 10^5	79.1	1.2 x 10^-3

  * Corrected volume at test temperature

Conclusions:

The vapour pressure of the test substance at 25 °C is lower than 1.4E-7 Pa.

Executive summary:

The vapour pressure of the test substance was determined by the gas saturation method in accordance with OECD TG 104 and following GLP principles. The vapour pressure of the test substance at 25 °C is lower than 1.4E-7 Pa.

Description of key information

Vapour pressure: 1.4E-7 Pa at 25 °C, OECD TG 104, gas saturation method, O’Connor 1992

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

25 °C