Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-221-4 | CAS number: 17169-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
- study conducted according to OECD guideline 471 (adopted July 21st, 1997), salmonella thyphimurium strains TA98, TA100, TA102, TA1535 and TA1537 were incubated with 50, 15, 5, 15, and 500 µg/plate in the first experiment (plate incorporation method) and with 78, 156, 313, 625, 1250, 250, and 5000 µg/plate in the second experiment (pre-incubation method). The plates were incubated for 48h at 37 ± 1°C and subsequently the number of revertants were counted, no genotoxicity, no cytotoxicity
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019-12-11 to 2020-02-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- adopted 21 July, 1997
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
- Target gene:
- his locus
- Species / strain / cell type:
- S. typhimurium TA 1537
- Additional strain / cell type characteristics:
- not applicable
- Species / strain / cell type:
- S. typhimurium TA 1535
- Additional strain / cell type characteristics:
- not applicable
- Species / strain / cell type:
- S. typhimurium TA 102
- Additional strain / cell type characteristics:
- not applicable
- Species / strain / cell type:
- S. typhimurium TA 100
- Additional strain / cell type characteristics:
- not applicable
- Species / strain / cell type:
- S. typhimurium TA 98
- Additional strain / cell type characteristics:
- not applicable
- Metabolic activation:
- with and without
- Metabolic activation system:
- Type and composition of metabolic activation system:
S9 liver Mix
- source of S9 : S9 was obtained by Trinova Biochem GmbH, Gießen.
- method of preparation of S9 mix: produced from the livers of male Sprague-Dawley rats which were treated with 500 mg Aroclor 1254/kg body weight intra-peritoneally.
- concentration or volume of S9 mix and S9 in the final culture medium: 500µL - Test concentrations with justification for top dose:
- nominal concentrations: 0, 50, 150, 500, 1500, 5000 µg/plate Experiment 1 and 0, 78, 156, 313, 625, 1250, 2500, 5000 µg/plate Experiment 2
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO; demineralized water
- Justification for choice of solvent/vehicle: DMSO was chosen due to the solubility of the positive controls 4-Nitro-1,2-phenylene diamine, benzo-a-pyrene and 2-amino anthracene - Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- sodium azide
- benzo(a)pyrene
- other: 4-Nitro-1,2-phenylene diamine: without metabolic activation, TA98, TA102, TA1537, 20 µg (TA98) and 30 µg (TA102 and TA1537) 2-Amino-anthracene: with metabolic activation, TA 100, TA102, TA1535, TA1537, 1µg (TA100, TA1535) and 2.4 µg (TA102, TA1537)
- Details on test system and experimental conditions:
- NUMBER OF REPLICATIONS:
- Number of cultures per concentration: triplicate for each with and without metabolic acitvation
- Number of independent experiments : 2
METHOD OF TREATMENT/ EXPOSURE:
- Cell density at seeding (if applicable): > E+09 cells/mL
- Test substance added in agar (plate incorporation)and in the second experiment with preincubation
METHODS FOR MEASUREMENT OF CYTOTOXICITY
- Method: background growth inhibition
- Any supplementary information relevant to cytotoxicity: No cytotoxicity nor precipitation occurred with the test item during the experimental time.
- Rationale for test conditions:
- as recommended by OECD Testguideline 471
- Evaluation criteria:
- The colonies were counted visually and the numbers were recorded. A substance is considered to be mutagenic, if a reproducible increase with or without metabolic activation of revertant colonies per plate exceeding an increase factor of 2 for the bacteria strains TA98, TA100, TA102, TA1535 and TA1537 compared to vehicle controls in at least one strain can be observed. A concentration-related increase over the range tested is also taken as a sign of mutagenic activity. A substance is not mutagenic if it does not meet these criteria. If the criteria listed above are not clearly met, the results will be assessed as equivocal and will be discussed.
- Statistics:
- The colonies were counted visually and the numbers were recorded. A validated spread-sheet software (Microsoft Excel®) was used to calculate mean values and standard deviations of each treatment, solvent control and positive control.
- Key result
- Species / strain:
- S. typhimurium TA 1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity nor precipitates, but tested up to recommended limit concentrations
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- True negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks:
- The positive control of strain TA 1537 was slightly outside the historical data. However, since the number of revetants was increased this was not considered to reduce the validity of the test result.
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity nor precipitates, but tested up to recommended limit concentrations
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- True negative controls validity:
- not examined
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity nor precipitates, but tested up to recommended limit concentrations
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- True negative controls validity:
- not examined
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity nor precipitates, but tested up to recommended limit concentrations
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- True negative controls validity:
- not examined
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity nor precipitates, but tested up to recommended limit concentrations
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- True negative controls validity:
- not examined
- Positive controls validity:
- valid
- Additional information on results:
- TEST-SPECIFIC CONFOUNDING FACTORS
- Data on pH: not reported
- Water solubility: The test item is not completely soluble in a concentration of 50 g/L in any of the solvents directly after preparation. But after a storage of 24 hours at room temperature (20 ± 5 °C) and vortexing, the test item in demin. water appeared soluble.
RANGE-FINDING/SCREENING STUDIES (if applicable):
In a non-GLP pre-test, the solubility of the test item was tested in a concentration of 50 g/L in demineralised (demin.) water, dimethyl sulfoxide (DMSO), acetone, ethanol and tetrahydrofuran (THF). The test item is not completely soluble in a concentration of 50 g/L in any of the solvents directly after preparation. But after a storage of 24 hours at room temperature (20 ± 5 °C) and vortexing, the test item in demin. water appeared soluble. Based on these results of the non-GLP pre-test, a test item suspension containing 50 ± 5 g/L in demin. water was prepared
STUDY RESULTS
- Concurrent vehicle negative and positive control data Please refer to 'Any other infomation on results incl. tables'
Ames test:
- Signs of toxicity : No
- Individual plate counts : Please refer to 'Any other information on results incl. tables'.
- Mean number of revertant colonies per plate and standard deviation: Please refer to 'Any other information on results incl. tables'.
HISTORICAL CONTROL DATA (with ranges, means and standard deviation, and 95% control limits for the distribution as well as the number of data)
- Positive historical control data: Please refer to 'Any other information on results incl. tables'.
- Negative (solvent/vehicle) historical control data: Please refer to 'Any other information on results incl. tables'. - Conclusions:
- There was no evidence of induced mutant colonies over background, when ferrous glycinate sulfate was tested with and without metabolic activation up to the recommended limit concentration (5000 µg/plate).
- Executive summary:
In a reverse gene mutation assay in bacteria according to EU Method B.14 (Version Commission Directive 92/69/EEC), strains TA1535, TA 1537, TA 102, TA 100 and TA 98of S. typhimurium were exposed to Ferrous glycinate sulfate. Test was performed with concentrations up to the recommended limit concentration of 5000 µg/plate in the absence and the presence of mammalian metabolic activation.
No evidence of biologically significant mutagenic activity of the test item was found in the presence and absence of metabolic activation, up to the limit concentration of 5000 µg/plate. The positive controls induced the appropriate responses in the corresponding strains and activity of metabolizing system was confirmed.
There was no evidence of induced mutant colonies over background.
Based on the presented data ferrous monoglycinate sulfate is not considered mutagenic and does not need to be classified according to Regulation (EC) No. 1272/2008 (CLP) and the globally Harmonized System for Classification and Labelling of Chemicals (GHS).
Reference
Table 1: Number of revertants per plate (mean of 3 plates), first experiment
|
|
TA98 |
|
TA100 |
TA102 |
|
TA1535 |
|
TA1537 |
|||||||||||
Conc. |
— MA |
Cytotoxic Precipitates (yes/no) |
+ MA |
Cytotoxic Precipitates (yes/no) |
— MA |
Cytotoxic Precipitates (yes/no) |
+ MA |
Cytotoxic Precipitates (yes/no) |
— MA |
Cytotoxic Precipitates (yes/no) |
+ MA |
Cytotoxic Precipitates (yes/no) |
— MA |
Cytotoxic Precipitates (yes/no) |
+ MA |
Cytotoxic Precipitates (yes/no) |
— MA |
Cytotoxic Precipitates (yes/no) |
+ MA |
Cytotoxic Precipitates (yes/no) |
DMSO |
11 |
no |
15 |
no |
77 |
no |
83 |
no |
325 |
no |
339 |
no |
7 |
no |
9 |
no |
9 |
no |
12 |
n--o |
0* |
13 |
no |
14 |
no |
85 |
no |
80 |
no |
341 |
no |
325 |
no |
8 |
no |
7 |
no |
9 |
no |
10 |
|
50 |
13 |
no |
14 |
no |
69 |
no |
67 |
no |
317 |
no |
328 |
no |
11 |
no |
13 |
no |
8 |
no |
9 |
no |
150 |
12 |
no |
15 |
no |
70 |
no |
76 |
no |
328 |
no |
325 |
no |
8 |
no |
8 |
no |
11 |
no |
9 |
no |
500 |
13 |
no |
13 |
no |
66 |
no |
75 |
no |
336 |
no |
339 |
no |
7 |
no |
11 |
no |
12 |
no |
10 |
no |
1500 |
15 |
no |
13 |
no |
65 |
no |
74 |
no |
333 |
no |
325 |
no |
10 |
no |
11 |
no |
8 |
no |
8 |
no |
5000 |
11 |
no |
12 |
no |
75 |
no |
71 |
no |
323 |
no |
328 |
no |
9 |
no |
9 |
no |
9 |
no |
10 |
no |
Positive control |
645 |
no |
102 |
no |
sg |
no |
sg |
no |
725 |
no |
824 |
no |
389 |
no |
243 |
no |
133 |
no |
195 |
no |
*solvent/vehicle control with water
Table 2: Number of revertants per plate (mean of 3 plates), second experiment
|
|
TA98 |
|
TA100 |
TA102 |
|
TA1535 |
|
TA1537 |
|||||||||||
Conc. |
— MA |
Cytotoxic Precipitates (yes/no) |
+ MA |
Cytotoxic Precipitates (yes/no) |
— MA |
Cytotoxic Precipitates (yes/no) |
+ MA |
Cytotoxic Precipitates (yes/no) |
— MA |
Cytotoxic Precipitates (yes/no) |
+ MA |
Cytotoxic Precipitates (yes/no) |
— MA |
Cytotoxic Precipitates (yes/no) |
+ MA |
Cytotoxic Precipitates (yes/no) |
— MA |
Cytotoxic Precipitates (yes/no) |
+ MA |
Cytotoxic Precipitates (yes/no) |
DMSO |
21 |
no |
29 |
no |
64 |
no |
61 |
no |
280 |
no |
283 |
no |
9 |
no |
9 |
no |
6 |
no |
8 |
no |
0* |
28 |
no |
33 |
no |
70 |
no |
69 |
no |
275 |
no |
275 |
no |
9 |
no |
7 |
no |
6 |
no |
9 |
no |
78 |
18 |
no |
22 |
no |
53 |
no |
75 |
no |
253 |
no |
259 |
no |
9 |
no |
8 |
no |
6 |
no |
7 |
no |
156 |
19 |
no |
19 |
no |
53 |
no |
64 |
no |
261 |
no |
269 |
no |
8 |
no |
7 |
no |
6 |
no |
6 |
no |
313 |
23 |
no |
21 |
no |
55 |
no |
59 |
no |
291 |
no |
277 |
no |
7 |
no |
7 |
no |
7 |
no |
6 |
no |
625 |
20 |
no |
19 |
no |
55 |
no |
57 |
no |
333 |
no |
336 |
no |
8 |
no |
8 |
no |
6 |
no |
7 |
no |
1250 |
16 |
no |
18 |
no |
64 |
no |
56 |
no |
304 |
no |
387 |
no |
9 |
no |
9 |
no |
5 |
no |
6 |
no |
2500 |
21 |
no |
19 |
no |
53 |
no |
68 |
no |
293 |
no |
331 |
no |
10 |
no |
7 |
no |
5 |
no |
5 |
no |
5000 |
24 |
no |
17 |
no |
65 |
no |
67 |
no |
339 |
no |
339 |
no |
8 |
no |
10 |
no |
6 |
no |
6 |
no |
Positive control |
sg |
no |
199 |
no |
421 |
no |
sg |
no |
717 |
no |
680 |
no |
325 |
no |
71 |
no |
139 |
no |
99 |
no |
*solvent/vehicle control with water
Demin. water Experiment 1/Vehicle control
Strain |
TA98 |
TA100 |
TA102 |
TA1535 |
TA1537 |
|||||
Induction |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
Repl.1 |
17 |
15 |
92 |
88 |
352 |
320 |
9 |
8 |
10 |
10 |
Repl.2 |
10 |
14 |
80 |
76 |
320 |
328 |
9 |
6 |
9 |
11 |
Repl.3 |
12 |
13 |
84 |
76 |
352 |
328 |
7 |
7 |
8 |
10 |
Mean |
13 |
14 |
85 |
80 |
314 |
325 |
8 |
7 |
9 |
10 |
sd |
3.6 |
1.0 |
6.1 |
6.9 |
18.5 |
4.6 |
1.2 |
1.0 |
1.0 |
0.6 |
DMSO Experiment 1/Vehicle control
Strain |
TA98 |
TA100 |
TA102 |
TA1535 |
TA1537 |
|||||
Induction |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
Repl.1 |
10 |
15 |
76 |
76 |
336 |
344 |
7 |
9 |
10 |
12 |
Repl.2 |
12 |
17 |
76 |
80 |
328 |
336 |
7 |
7 |
7 |
13 |
Repl.3 |
11 |
13 |
80 |
92 |
312 |
336 |
8 |
12 |
9 |
10 |
Mean |
11 |
15 |
77 |
83 |
325 |
339 |
7 |
9 |
9 |
12 |
sd |
1.0 |
2.0 |
2.3 |
8.3 |
12.2 |
4.6 |
0.6 |
2.5 |
1.5 |
1.5 |
Positive control Experiment 1
Strain |
TA98 |
TA100 |
TA102 |
TA1535 |
TA1537 |
|||||
Induction |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
Substance |
NPD |
BaP |
Na-azide |
2-AA |
NPD |
2-AA |
Na-azide |
2-AA |
NPD |
2-AA |
Repl.1 |
704 |
99 |
sg |
sg |
744 |
840 |
384 |
240 |
128 |
202 |
Repl.2 |
664 |
99 |
sg |
sg |
728 |
816 |
376 |
240 |
132 |
194 |
Repl.3 |
568 |
107 |
sg |
sg |
704 |
816 |
408 |
248 |
138 |
190 |
Mean |
645 |
102 |
-- |
-- |
725 |
824 |
389 |
243 |
133 |
195 |
sd |
69. |
4.6 |
-- |
-- |
20.1 |
13.9 |
16.7 |
4.6 |
5.0 |
6.1 |
f(l) |
58.64 |
6.80 |
> 2 |
> 2 |
2.23 |
2.43 |
48.63 |
27.00 |
14.78 |
16.25 |
Rev. abs. |
634 |
87 |
-- |
-- |
400 |
485 |
381 |
234 |
124 |
183 |
s.g.= strong growth, too strong for counting of revertants
f(l) = increase factor
Rev.abs. = absolute revertants
Demin. Water Experiment 2/Vehicle control
Strain |
TA98 |
TA100 |
TA102 |
TA1535 |
TA1537 |
|||||
Induction |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
Repl.1 |
30 |
32 |
68 |
66 |
280 |
272 |
11 |
6 |
6 |
9 |
Repl.2 |
28 |
35 |
68 |
70 |
272 |
280 |
8 |
7 |
6 |
10 |
Repl.3 |
25 |
31 |
74 |
70 |
272 |
272 |
7 |
9 |
7 |
8 |
Mean |
28 |
33 |
70 |
69 |
275 |
275 |
9 |
7 |
6 |
9 |
sd |
2.5 |
2.1 |
3.5 |
2.3 |
4.6 |
4.6 |
2.1 |
1.5 |
0.6 |
1.0 |
DMSO Experiment 2/Vehicle control
Strain |
TA98 |
TA100 |
TA102 |
TA1535 |
TA1537 |
|||||
Induction |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
Repl.1 |
23 |
30 |
64 |
58 |
288 |
280 |
8 |
8 |
8 |
7 |
Repl.2 |
21 |
28 |
62 |
60 |
272 |
288 |
11 |
8 |
5 |
7 |
Repl.3 |
20 |
30 |
66 |
64 |
280 |
280 |
9 |
12 |
6 |
9 |
Mean |
21 |
29 |
64 |
61 |
280 |
283 |
9 |
9 |
6 |
8 |
sd |
1.5 |
1.2 |
2.0 |
3.1 |
8.0 |
4.6 |
1.5 |
2.3 |
1.5 |
1.2 |
Positive control Experiment 2
Strain |
TA98 |
TA100 |
TA102 |
TA1535 |
TA1537 |
|||||
Induction |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
Substance |
NPD |
BaP |
Na-azide |
2-AA |
NPD |
2-AA |
Na-azide |
2-AA |
NPD |
2-AA |
Repl.1 |
sg |
192 |
400 |
sg |
728 |
680 |
320 |
70 |
132 |
92 |
Repl.2 |
sg |
196 |
424 |
sg |
704 |
704 |
320 |
73 |
140 |
108 |
Repl.3 |
sg |
208 |
440 |
sg |
720 |
656 |
336 |
71 |
144 |
96 |
Mean |
-- |
199 |
421 |
-- |
717 |
680 |
325 |
71 |
139 |
99 |
sd |
-- |
8.3 |
20.1 |
-- |
12.2 |
24.0 |
9.2 |
1.5 |
6.1 |
8.3 |
f(l) |
> 2 |
6.86 |
6.01 |
> 2 |
2.56 |
2.40 |
36.11 |
7.89 |
23.17 |
12.38 |
Rev. abs. |
-- |
170 |
351 |
-- |
437 |
397 |
316 |
62 |
133 |
91 |
s.g.= strong growth, too strong for counting of revertants
f(l) = increase factor
Rev.abs. = absolute revertants
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
In a reverse gene mutation assay in bacteria according to EU Method B.14 (Version Commission Directive 92/69/EEC), strains TA1535, TA 1537, TA 102, TA 100 and TA 98of S. typhimurium were exposed to ferrous monoglycinate sulfate. Test was performed with concentrations up to the recommended limit concentration of 5000 µg/plate in the absence and the presence of mammalian metabolic activation.
No evidence of biologically significant mutagenic activity of the test item was found in the presence and absence of metabolic activation, up to the limit concentration of 5000 µg/plate. The positive controls induced the appropriate responses in the corresponding strains and activity of metabolizing system was confirmed.
There was no evidence of induced mutant colonies over background.
Based on the available data ferrous monoglycinate sulfate is not classified as mutagen according to Regulation (EU) No. 1272/2008 (CLP) andf the Globally Harmonized System for Classification and Labelling of Chemicals (GHS) .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.