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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 224-929-8 | CAS number: 4559-86-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- : no histopathologic examination
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: ChR-CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no further data
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Amount applied: 3.1 - 5.66 mL
- Doses:
- 6250, 9000, 14624, 17206 or 19789 mg/kg bw
- No. of animals per sex per dose:
- 10 m
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
Necropsy of survivors performed: no
Other examinations performed: clinical signs and body weight - Statistics:
- Probit
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 16 742 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 14 422 - 20 325
- Mortality:
- 0/10, 0/10, 4/10, 5/10 and 7/10
- Clinical signs:
- other: >= 6250 mg/kg: salivation, wet and stained perianal area, congestion, stained mouth, nose and feet, chromodacryorrhea, alopecia, tremors, fasciculations, piloerection, and weight loss >= 9000 mg/kg: diarrhoea, weakness and ruffled fur >= 14624 mg/kg: eyes
- Gross pathology:
- no data
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- With an oral LD50 value of 16742 mg/kg bw in rats, 1,1,3,3-tetrabutyl-urea is practically nontoxic.
- Executive summary:
1,1,3,3-tetrabutyl-urea was tested in an acute oral toxicity study with rats. Five groups of 10 male ChR-CD rats were dosed once via gavage with 6250, 9000, 14624, 17206 or 19789 mg/kg bw. With an oral LD50 value of 16742 mg/kg bw, 1,1,3,3 -tetrabutyl-urea was practically nontoxic.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 16 742 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference not available (only very brief summary)
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- not further specified
- GLP compliance:
- no
- Test type:
- other: not further specified
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- no data
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 7 500 mg/kg bw
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- For the test substance a LD50 value of > 7500 mg/kg bw was given.
- Executive summary:
For male rabbits a dermal LD50 value of > 7500 mg/kg bw has been reported.
Reference
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 7 500 mg/kg bw
Additional information
1,1,3,3-tetrabutyl-urea was tested in an acute oral toxicity study with rats. Five groups of 10 male ChR-CD rats were dosed once via gavage with 6250, 9000, 14624, 17206 or 19789 mg/kg bw. With an oral LD50 value of 16742 mg/kg bw, 1,1,3,3-tetrabutyl-urea was practically nontoxic.
For male rabbits a dermal LD50 value of > 7500 mg/kg bw has been reported.
Justification for classification or non-classification
From the available data it can be concluded that the acute toxicity of 1,1,3,3-tetrabutylurea is low. Therefore, there is no need for classification and labelling.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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