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EC number: 200-735-9 | CAS number: 70-47-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- subchronic (90 d study) repeated dose toxicity study oral (diet), rat Fischer 344/DuCrj m/f (OECD TG 408), dose levels: 1.25%, 2.5%, and 5% , corresponding to 857, 1708 and 3466 mg/kg bw/day (females) and 753, 1537 and 3242 mg/kg bw/day(males); NOAEL = 1730 mg/kg bw/day (females) and 1650 mg/kg bw/day (males).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 1 650 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- The available study was conducted according to guideline and is of high quality. Additionally, supporting data with methodological limitations are available.
- System:
- other: Clinical biochemistry, body and organ weights
- Organ:
- brain
- kidney
- testes
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Fischer/344DuCrj rats were administered L-asparagine (1.25, 2.5 and 5%, corresponding to 857, 1708 and 3466 mg/kg bw/day act. ing. (females) and 753, 1537 and 3242 mg/kg bw/day act. ing. (males) in the diet for 90 days according to OECD guideline 408. At the highest dose, the treatment-related findings were changes in clinical biochemistry, body and organ weight changes and microscopic changes in the lungs, ovaries and Zymbal´s glands. At 2.5% ALP was decreased in male rats but there was no dose-response relationship. In 5% treated females, GLU, PL, TG, K and ALT were significantly increased and at 2.5% TG was increased. In 1.25% treated females, GLU and TG were also increased and CRN was decreased. Significant increases of relative organ weights of the brain, kidney and testes were observed in 5% treated males. Hence, the NOAEL was considered to be 2.5% (i.e., equivalent to 1650/1730 mg a.i./kg bw/d).
In the supporting study male Wistar rats were administered 210 mg/kg bw/d L-asparagine and observed for 14 days. Since this study was conducted in order to determine the body weight gain of a diet supplemented with amino acids the results reported are considered not relevant in terms of information requirement for registration according to Regulation (EC) No 1907/2006 but provided further indications for a low oral toxicity of L-asparagine.
Justification for classification or non-classification
Based on the available, relevant and adequate data the substance does not need to be classified according to Regulation (EC) No 1272/2008 (CLP) and the Globally Harmonized System for Classification and Labeling of Chemicals (GHS) with respect to specific target organ toxicity-repeated exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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