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Diss Factsheets
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EC number: 208-761-2 | CAS number: 540-92-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- A routine inspection by FDA at Industrial Bio-Test laboratories (IBT) in 1976 uncovered numerous discrepancies between raw data and study reports, and gross deficiencies in study conduct; mainly in non-acute studies, but also in acute toxicity studies. Thus, study reports from IBT between the 1960´s and until 1978 should be taken with care. An important consideration is the consistency of the findings from the IBT study with findings from other studies that were conducted at reputable test houses at a later date to the IBT study (to rule out the possibility of data being manipulated by IBT to be consistent with existing data). REFERENCE: OECD (2005): Manual for investigation of HPV Chemicals, Chapter 3: Data Evaluation (3.1 Guidance for Determining the Quality of Data fo the SIDS Dossiers: Reliability, relevance and adequacy, 3.1.8 Acceptance and use of studies from Industrial Bio-Test laboratories. OECD - Manual for the Assessment of Chemicals (http://www.oecd.org/chemicalsafety/risk-assessment/chapter3dataevaluation.htm)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Purity of the test material was not listed.
- GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium 2-hydroxypropane-2-sulphonate
- EC Number:
- 208-761-2
- EC Name:
- Sodium 2-hydroxypropane-2-sulphonate
- Cas Number:
- 540-92-1
- Molecular formula:
- C3H8O4S.Na
- IUPAC Name:
- sodium 2-hydroxypropane-2-sulphonate
- Test material form:
- solid
- Details on test material:
- white powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Rats
- Age at study initiation: young adult
- Housing: stock cages
- Diet (e.g. ad libitum): standard laboratory diet (Wayne LAB-BLOX for Rats, Chicago, USA)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- The dust was suspended by passing clean, dry air (-40° C dewpoint) through a dust shaker rnechanisrn. The resulting air-dust rnixture was then introduced into the exposure charnber. Each animal was caged separately during exposure to minimize filtration of inspired air by animal fur. The average analytical concentration of airborne dust was obtained by repeated air sampling.
- Duration of exposure:
- 4 h
- Concentrations:
- 1530 mg/m³ air (maximum attainable concentraion under the conditons stated,)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: prior to inhaltion exposur and at the end of the observation period
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 530 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- There were no deaths during exposure or the 14-day observation period which followed.
- Clinical signs:
- other: Red nasal discharge was observed in 1 test animal after 180 minutes of exposure. This reaction lasted >8<18 hrs.
- Body weight:
- The average 2-week body weight gains were within the normal limits.
- Gross pathology:
- Complete nec ropsies were done on all male and female rats us ed in this experiment when the study was terminated at the end of the 14-day post-exposure observation period. No gross tissue changes attributable to the effects of the test material were observed in any of the rats examined.
Any other information on results incl. tables
Group No. |
Total Number of Animals Male/Female |
Analytical Concentration (mg/m³ air) |
Mortality Male - Female |
Weight Gain Male -female (grams) |
Test |
5/5 |
1530* |
0/5 – 0/5 |
81 - 31 |
*Maximum attainable concentration under the conditions stated.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.