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EC number: 270-220-1 | CAS number: 68413-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other:
- Adequacy of study:
- key study
- Study period:
- May 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information selected for the toxicokinetic assessment is primarily study data. Studies were conducted inaccordance with recognised testing guidelines.
- Conclusions:
- In conclusion, based upon the available data, bioavailability ofthe substance, Butanedioic acid, 2-[[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]-, 1,4-dibutyl ester (CASRN 68413-48-9),is expected to be very limited and the substance has low systemic toxicity.
Reference
The physical state of the substance, Butanedioic acid, 2-[[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]-, 1,4-dibutyl ester (CASRN 68413-48-9),is a pale yellow, clear liquid at room temperature and therefore, potential inhalation of the substance is negligible.
The water solubility is expected to be very low and partition coefficient (Log Pow) of the substance is > 6.5, respectively. The typical molecular mass of the substance (C28H55O6PS2) is 582.84 Daltons. These data indicate that the substance is relatively large (> 500 Daltons), has very low water solubility (< 0.1 mg/L), and is a highly lipophilic (Log Pow > 5.6) molecule, and therefore, the substance is not bioavailable via the oral route in accordance with Lipinski's rule of five. In addition, acute oral toxicity study of the substance in rats concluded its oral LD50of 11300 mg/kg body weight. Repeated dose oral toxicity studies in rats did not show any systemic effects up to 1000 mg/kg/day, the highest doses tested in both 14-day oral toxicity study and combined repeated dose oral toxicity study with the reproductive/developmental toxicity screening test. No information is currently available on possible degradation products produced in the gastrointestinal tract.
The very low water solubility, high lipophilicity, and relatively large molecular mass of the substance also indicate that it is not expected to be absorbed via the dermal route. Skin irritation test in rabbits showed that the substance is not a skin irritant. Although thelocal lymph node assay (LLNA) in mouse showed an EC3of 50.1% that was likely due to an impurity of the test substance,dibutyl fumarate (CASRN 105-75-9), under the conditions of the test. The purity of the test item used in the LLNA was 84% and the certificate of analysis showed the test item contained approximately 0.5% (w/w) dibutyl fumarate, a known sensitizer, based on the MS area from LC-MS. The quantitative structure-active relationship (QSAR) analysis showed that the substance had no protein binding alerts. Therefore, the substance itself was not considered to be a skin sensitizer.
Additionally, the ready biodegradability test of the substance showed that it was not readily biodegradable. The measured test concentrations of the substance in aquatic medium were extremely low, approximately0.0024mg/L in the acute toxicity test in fish. The substance is therefore expected to have low potential for bioaccumulation in aquatic organisms although the substance is persistent and its Log Pow exceeds 5.
In conclusion, based upon the available data, bioavailability ofthe substance, Butanedioic acid, 2-[[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]-, 1,4-dibutyl ester (CASRN 68413-48-9),is expected to be very limited and the substance has low systemic toxicity.
Description of key information
Based upon the available data, bioavailability of the substance, Butanedioic acid, 2-[[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]-, 1,4-dibutyl ester (CASRN 68413-48-9), is expected to be very limited and the substance has low systemic toxicity.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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