Registration Dossier
Registration Dossier
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EC number: 270-220-1 | CAS number: 68413-48-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 February 1981 to 16 February 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: 1500.42 of C.F.R. 16 of the U.S. Federal Hazardous Substances Act Regulations
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dibutyl [[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]succinate
- EC Number:
- 270-220-1
- EC Name:
- Dibutyl [[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]succinate
- Cas Number:
- 68413-48-9
- Molecular formula:
- C28H55O6PS2
- IUPAC Name:
- 1,4-dibutyl 2-({bis[(2-ethylhexyl)oxy](sulfanylidene)-λ⁵-phosphanyl}sulfanyl)butanedioate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Date received: 28 January 1981
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Remarks:
- albino
- Details on test animals or tissues and environmental conditions:
- The animals were housed and maintained in compliance with the Animal Welfare Act (Pub. L- 94- 279) 9 CFR Part 3.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL
- Observation period (in vivo):
- One, two, three, five and seven days following test item administration
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.94
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72hr
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.83
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72hr
- Remarks on result:
- probability of mild irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material is not an ocular irritant in the eye.
- Executive summary:
In a study performed according to 16 C.F.R. 1500.42 of the U.S. Federal Hazardous Substances Act Regulations the test material is not an ocular irritant.
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