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Diss Factsheets
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EC number: 946-354-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: read-across from constituent CrIII
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Safety and toxicological evaluation of a novel niacin-bound chromium (III) complex.
- Author:
- Shara M, Yasmin T, Kincaid AE, Limpach AL, Bartz J, Brenneman KA, Chatterjee A, Bagchi M, Stohs SJ, Bagchi D.
- Year:
- 2 005
- Bibliographic source:
- J Inorg Biochem. 2005 Nov;99(11):2161-83
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Cr III
- Molecular formula:
- Cr III
- IUPAC Name:
- Cr III
- Test material form:
- solid
- Details on test material:
- Niacin bound chromium (NBC) is a unique, patented oxygen-coordinated niacin-bound chromium complex commercially known as ChromeMate CM-100M (powder) and was obtained from InterHealth Nutraceuticals, Benicia, CA, USA.
Lot#306013
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals, Inc., (Boyertown, PA, USA)
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: 12 h light/12 h dark
- Weight at study initiation:male and female 298–310 and 199–205 g
- Fasting period before study: not reported
- Housing: not reported
- Diet (e.g. ad libitum): lab chow (Purina Rodent Chow No. 5012, St. Louis, MO, USA)
- Water (e.g. ad libitum): municipal water ad libitum
- Acclimation period: 13 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18–22 °C
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): 12 h light/12 h dark
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- Doses were calculated based on the initial body weights obtained prior to dosing with a 2000 mg/kg b.w.
On the day prior to application, the hair was removed by clipping the dorsal area and the trunk using an Oster model #A5-small clipper.
After clipping and prior to application, the animals were examined for health, weighed (initial) and the skin checked for any abnormalities.
The test product was moistened with distilled water to achieve a dry paste by preparing a 70% w/w mixture.
The test product was then applied to a 2 inch * 3 inch, 4-ply gauze pad and placed on the animal (approximately 10% of the body surface).
The gauze pad and entire trunk of each animal were then wrapped with 3-inch Durapore tape to avoid dislocation of the pad and to minimize loss of the test substance. - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/lg bw
- No. of animals per sex per dose:
- five
- Control animals:
- no
- Statistics:
- No statistics due to absence of effects
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 621.6 mg/kg bw
- Based on:
- act. ingr.
- Remarks:
- CrIII
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No adverse clinical signs were observed. All animals remained active and healthy troughout the observation period.
- Gross pathology:
- No gross abnormalities were noted for any of the animals at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal toxicity to rats was found as LD50 >2000 mg/kg bw or 621.6 mg/kg bw for CrIII. No mortality was observed and no adverse effects were noted.
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