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EC number: 275-640-9 | CAS number: 71566-55-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 Okt 1979 to 22 Jan 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Appraisel of the Safety of Chemicals in Foods, Drugs and Cosmetics (US 1959)
- GLP compliance:
- no
- Type of study:
- Maurer optimisation test
- Justification for non-LLNA method:
- Currently no LLNA study is available for assessment. The Maurer optimisation test has been carried out as an animal test to predict human sensitization for over a decade and is recommended by international test guidelines such as OECD.
Test material
- Reference substance name:
- 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium bis[3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-4-hydroxy-N-3-(isopropoxypropyl)benzenesulphonamidato(2-)]cobaltate(1-)
- EC Number:
- 275-640-9
- EC Name:
- 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium bis[3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-4-hydroxy-N-3-(isopropoxypropyl)benzenesulphonamidato(2-)]cobaltate(1-)
- Cas Number:
- 71566-55-7
- Molecular formula:
- C44H50CoN10O10S2.C28H31N2O3
- IUPAC Name:
- 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium bis[3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-4-hydroxy-N-3-(isopropoxypropyl)benzenesulphonamidato(2-)]cobaltate(1-)
- Test material form:
- solid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Pirbright-Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Bantin and Kingman Ldt. Grimston, Hull, England
- Weight at study initiation: 305 to 400 g
- Housing: The animals were housed individually in Macrolon cages
- Diet: The animals received ad libitum standard guinea pig pellets - NAFAG, No. 830, Gossau SG - and water
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 2 °C
- Humidity: 55 ± 10 %
- Photoperiod: 10 hours light cycle day
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- propylene glycol
- Concentration / amount:
- 0.1 % suspension of the test substance
- Day(s)/duration:
- 1st week: 1 intracutaneous injection every second day
- Route:
- intradermal
- Vehicle:
- other: (propylen glycol : Bacto Adjuvant) = 1:1
- Concentration / amount:
- 0.1% suspension of the test substance
- Day(s)/duration:
- 2nd & 3rd week: 1 intracutaneous injection every second day
Challengeopen allclose all
- No.:
- #1
- Route:
- intradermal
- Vehicle:
- propylene glycol
- Concentration / amount:
- 0.1 mL of 0.1 % suspension of the test substance
- Day(s)/duration:
- 14 days after the last sensitising injection
- No.:
- #2
- Route:
- other: epicutaneous
- Vehicle:
- other: vaseline
- Concentration / amount:
- 30 % suspension of the test substance
- No. of animals per dose:
- 10 males and 10 females per group
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: Three different injection procedures + challenge exposure + epicutaneous application:
1. One injection every second day to a total of 10 intracutaneous injections of a freshly prepared 0.1 % suspension of the test item in propylene glycol
2. On the first day, injection of 0.1 mL were administered into the shaven skin of the right flank and the back, while on the following days a single intracutaneous injection was given into the back.
3. During the second and third week of the induction period the test material was incorporated in a mixture of the normal vehicle with complete Bacto Adjuvant (vehicle : adjuvant = 1 : 1)
- Exposure period: 3 weeks
- Test groups: group of 10 males and 10 females
- Control group: one control group was treated with the vehicle alone (negative control)
B.1 CHALLENGE EXPOSURE (intradermal)
- Exposure period: fourteen days after the last sensitizing injection, a challenge injection of 0.1 mL of a freshly prepared 0.1 % suspension of the test item in propylene glycol was administrated into the skin of the left flank
B.2 CHALLENGE EXPOSURE (epidermal)
- 30 % suspension of the test item in vaseline - Positive control substance(s):
- no
Results and discussion
- Positive control results:
- no positive controls
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- other: first reading (intradermal challenge)
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.1 %
- No. with + reactions:
- 18
- Total no. in group:
- 20
- Reading:
- other: first reading (intradermal challenge)
- Hours after challenge:
- 24
- Group:
- negative control
- No. with + reactions:
- 4
- Total no. in group:
- 20
- Remarks on result:
- other: negative control
- Remarks:
- no concentration can be applied
- Key result
- Reading:
- other: first reading (epicutaneous challenge)
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 30 %
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Reading:
- other: first reading (epicutaneous challenge)
- Hours after challenge:
- 24
- Group:
- negative control
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: negative control
- Remarks:
- no concentration can be applied
Any other information on results incl. tables
Under the experimental conditions employed,
significant differences between the test group and the vehicle-treated
controls were only seen after intradermal challenge application of the
test item, i.e. when the skin barrier was intentionally by-passed.
No differences between the test and the
control group was seen after epidermal challenge application. The
negative results upon epidermal challenge demonstrate that, in
artificially sensitized guinea-pigs, exposure of the intact skin to the
test compound does not provoke contact dermatitis.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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