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EC number: 435-580-8 | CAS number: 56553-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: 300 mg/kg bw < LD50 < 2000 mg/kg bw (OECD 423)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-01-06 - 2004-03-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study according GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss Federal Office of Public Health, 2003
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CRR Ltd., Laboratory Animal Services, CH-4414 Füllinsdorf, Switzerland
- Age at study initiation: 10 – 11 weeks
- Weight at study initiation: mean 175.7
- Housing: In groups of three in Macrolon type-4 cages with wire mesh tops and standard softwood bedding (“Lignocell”, Schill AG, CH-4132 Muttenz, Switzerland
- Diet (e.g. ad libitum): Pelleted standard Provimi Kliba 3433 rat/mouse maintenance diet, batch No. 54/03 and 78/03 (Provimi Kliba AG, CH-4303 KAiseraugst, Switzerland); ad libitum
- Water (e.g. ad libitum): Community tap water from Füllinsdorf; ad libitum
- Fasting period before study: 15-19 h
- Acclimation period: not specified
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25
- Humidity (%): 30 - 70
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12 / 12 - Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.2, 0.03 g/mL
- Amount of vehicle (if gavage): 10 mL/kg
- Lot/batch no. (if required): 45256603
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: based on previous non-GLP study - Doses:
- 300 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 300 mg/kg bw: 6 females
2000 mg/kg bw: 3 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations for mortality /viability daily during acclimatization and twice daily during day 1-5; observation for clinical signs daily during acclimatization and approx. 0, 1, 2, 3 and 5 h after administration, once during days 2-15; weighing on day 0 prior to administration, days 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals of the high dosage group were found dead 50 min - 60 min after administration and on day 2, respectively. All animals of the low dose groups survived.
- Clinical signs:
- 2000 mg/kg bw: Moderate salivation, ruffled fur, sedation, ventral, recumbency, hunched posture, bluish discoloured feets and tail (only in 1 animal)
300 mg/kg bw: No clinical signs - Body weight:
- All body weight were in normal range common for this strain.
- Gross pathology:
- 2000 mg/kg bw: distended stomach with gas, discoloured left lateral lobe of liver, partly black forestomach and spleen, dark- red to black small intestine, pale to yellow discoloured kidneys
300 mg/kg bw: No macroscopic findings - Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of Sodium triacetoxyborohydride was found to be >300 and < 2000 mg/kg bw in female rats.
- Executive summary:
Acute oral toxicity of Sodium triacetoxyborohydride was evaluated in a GLP study performed according to OECD 423, where groups of female Wistar rats were administered with 300 ad 2000 mg/kg bw in corn oil, respectively. Based on mortality and clinical signs observed in the high dose group, the LD50 was found to be >300 and < 2000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 300 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-04-06 - 2005-05-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study according GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss Federal Office of Public Health, 2003
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CRR Ltd., Laboratory Animal Services, CH-4414 Füllinsdorf, Switzerland
- Age at study initiation: 8 - 9 weeks (males), 11 – 12 weeks (females)
- Weight at study initiation: mean 248.1 g (males), mean 197.7 g (females)
- Housing: In groups of three in Macrolon type-4 cages with wire mesh tops and standard softwood bedding (“Lignocell”, Schill AG, CH-4132 Muttenz, Switzerland
- Diet (e.g. ad libitum): Pelleted standard Provimi Kliba 3433 rat/mouse maintenance diet, batch No. 54/03 and 78/03 (Provimi Kliba AG, CH-4303 KAiseraugst, Switzerland); ad libitum
- Water (e.g. ad libitum): Community tap water from Füllinsdorf; ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25
- Humidity (%): 30 - 70
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12 / 12 - Type of coverage:
- semiocclusive
- Vehicle:
- polyethylene glycol
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back
- % coverage: 10
- Type of wrap if used: semi-occlusive dressing wrapped around the body and fixed with adhesive bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with PEG 300, the dried with paper towel
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 4 mL/kg bw
- Concentration (if solution): 0.5 g/mL
- Constant volume or concentration used: yes
VEHICLE
- Amount(s) applied (volume or weight with unit): 4 mL/kg bw
- Lot/batch no. (if required): 1078164 12004034 - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations for mortality /viability and clinical signs daily during acclimatization and approx. 0, 1, 2, 3 and 5 h after administration, once during days 2-15 d; weighing on day 0 prior to administration, days 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality during the study.
- Clinical signs:
- Slight general erythema in three animals on days 2 and 3 and in one animal on day 4.
- Body weight:
- All body weights were in normal range common for this strain.
- Gross pathology:
- No macroscopic findings.
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of Sodium triacetoxyborohydride for acute dermal toxicty was found to be >2000 mg/kg bw.
- Executive summary:
Acute dermal toxicity of Sodium triacetoxyborohydride was evaluated in a GLP study performed according to OECD 402, where groups of five male and female female Wistar rats were treated with 2000 mg/kg bw in PEG300 under semi-occlusive conditions for 24 h, respectively. Based on the absence of clinical signs and mortality, the LD50 was found to be >2000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity of Sodium triacetoxyborohydride was evaluated in a GLP acute performed according to OECD 423, where groups of female Wistar rats were administered with 300 ad 2000 mg/kg bw in corn oil, respectively. Based on mortality and clinical signs observed in the high dose group, the LD50 was found to be >300 and < 2000 mg/kg bw.
Acute dermal toxicity of Sodium triacetoxyborohydride was evaluated in a GLP study performed according to OECD 402, where groups of five male and female female Wistar rats were treated with 2000 mg/kg bw in PEG300 under semi-occlusive conditions for 24 h, respectively. Based on the absence of clinical signs and mortality, the LD50 was found to be >2000 mg/kg bw.
Justification for selection of acute toxicity – oral endpoint
Reliable OECD guideline study according to GLP
Justification for selection of acute toxicity – dermal endpoint
Reliable OECD guideline study according to GLP
Justification for classification or non-classification
The available data on acute toxicity of the test substance meet the criteria for classification as Acute Tox. 4 (H302: Harmful if swallowed) according to Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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