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EC number: 283-740-9 | CAS number: 84712-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 25 July 1979 to 29 August 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Draize Repeated Insult Patch Test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Acetic acid, C11-14-isoalkyl esters, C13-rich
- EC Number:
- 283-740-9
- EC Name:
- Acetic acid, C11-14-isoalkyl esters, C13-rich
- Cas Number:
- 84712-50-5
- Molecular formula:
- Not applicable (a generic molecular formula cannot be provided for this specific UVCB substance)
- IUPAC Name:
- Acetic acid, C11-14-isoalkyl esters, C13-rich
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: PA-279-3
- Expiration date of the lot/batch: no data
- Purity test date: no data
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: no data
- Stability under test conditions: no data
- Solubility and stability of the test substance in the solvent/vehicle: undiluted test substance
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 50
- Sex: male and female
- Age: no data
- Race: no data
- Demographic information: no data - Clinical history:
- - History of allergy or casuistics for study subject or populations: no data
- Symptoms, onset and progress of the disease: no data
- Exposure history: no data
- Aggravating factors both in home and workplace: no data
- Family history: no data
- Medical history (for respiratory hypersensitivity): no data
- Any other allergic or airway disorders: no data
- Smoking history: no data - Controls:
- no data
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION AND EXAMINATION
0.2 g of the test material was applied onto the arms of 50 volunteers (9 male and 41 female). The subjects ranged from 16 to 74 years of age. The samples were covered with a semi-occlusive covering of gauze and loosely applied Dermicel tape. The patches remained in place for 24 hours, after which the patches were removed. The excess material was wipes off and the test sites were examined.
The subjects were rested for another 24 hours after which the skin sited were again examined. The test substance was then applied second time, repeating the application procedure. This procedure was repeated 3 times a week for 3 weeks for a total of 9 applications. Two weeks later, challenge application was applied in the same manner to the same skin sites as well as to previously untreated sites on the same arm. The challenge applications were removed after 24 hours and the treated sites were examined for signs of skin irritation or sensitisation. The sites were re-examined at 48 and 72 hours after patch removal.
A subset of 20 volunteers (5 males and 15 females) were simultaneously studied by treating an identical site on the other arm with 0.2 g of the test material. These test sites were irradiated simultaneously. A 15-minute exposure period was utilized. The exposure distance was 15 inches from the lamp. The samples were covered with a semi-occlusive covering of gauze and loosely applied Dermicel tape. The patches remained in place for 24 hours, after which the patches were removed. The excess material was wipes off and the test sites were examined. 24 hours later the test sites were examined again. The experimental material was applied one more time to the same sites previously used. The irradiation procedure was applied at applications 1, 4, 7 and 9 and at the challenge application. The original and virgin sites were irradiated at challenge. The challenge applications were removed after 24 hours and the sites were examined at the time of patch removal, then at 48 and 72 hours post-exposure.
Results and discussion
- Results of examinations:
- Based on the results obtained, the test substance was not a primary skin irritant or a fatiguing agent. No sensitisation reactions were noted. Exposure to UV-A light does not appear to initiate or increase the incidence or severity of irritation, fatigue or sensitisation.
Applicant's summary and conclusion
- Conclusions:
- Based on the results obtained, the test substance was not a primary skin irritant or a fatiguing agent. No sensitisation reactions were noted. Exposure to UV-A light does not appear to initiate or increase the incidence or severity of irritation, fatigue or sensitisation.
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