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EC number: 231-768-7 | CAS number: 7723-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published report of human poisoning
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The paper describes a human suicidal intoxication with yellow phosphorus
- GLP compliance:
- no
Test material
- Reference substance name:
- Phosphorus
- EC Number:
- 231-768-7
- EC Name:
- Phosphorus
- Cas Number:
- 7723-14-0
- Molecular formula:
- P
- IUPAC Name:
- phosphorus
- Test material form:
- solid
- Details on test material:
- Elemental phosphorus is often referred to as yellow phsophorus
Constituent 1
- Specific details on test material used for the study:
- Impure white phosphorus is also referred to as yellow phosphorus.
Method
- Type of population:
- general
- Subjects:
- 19 year old female student
- Ethical approval:
- not applicable
- Route of exposure:
- oral
- Reason of exposure:
- intentional
- Details on exposure:
- The female human ingested about 10 g yellow phosphorus strand from a chemistry laboratory to commit suicide at about 02:00 hrs.
- Examinations:
- Blood pressure
- Medical treatment:
- The subject was admitted to hospital approximately 5 hours after ingesting the substance (07:00 hrs) and remained in hospital until her death, approximately 50 hours after ingestion.
Results and discussion
- Clinical signs:
- Repeated vomiting, dizziness, nausea, bradychardia, low blood pressure, intestinal spasms and respiratory failure.
- Results of examinations:
- No information available.
- Effectivity of medical treatment:
- The patient died.
- Outcome of incidence:
- The patient died.
Any other information on results incl. tables
Vomit and faeces ignited spontaneously in air, and a chair was ignited in the intensive care unit. Initially the patient vomited repeatedly (the vomit ignited in air), at which point she was admitted to hospital. After hospital admission, the patient showed no further symptoms except vomiting and blood pressure was stable at 120/60 mm Hg. She was then admitted to a psychiatric ward at 12:00 hrs. During the evening and night she complained of dizziness and nausea, blood pressure was stable at 130/75. The condition of the patient then deteriorated. The following night (2 days after initial ingestion) the blood pressure fell to 90/60, there were intestinal spasms and respiratory failure. She was admitted to the intensive care unit, she exhibited gasping and bradychardia. The patient was intubated and received pacemaker therapy and emergency infusion. Treatment was unsuccessful and the patient died 1 hour later, approximately 50 hours after initial ingestions.
Applicant's summary and conclusion
- Conclusions:
- The oral ingestion of phosphorus proved fatal.
- Executive summary:
A case of suicidal intoxication with yellow phosphorus was studied. The clinical course showed the typical three stages including a symptom free period, although death occurred within 50 hours from acute toxic damage of the myocardium.
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