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EC number: 203-896-3 | CAS number: 111-69-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 days
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Values were conducted using method of D.J Finney. Material was defined.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
- Principles of method if other than guideline:
- Method: Groups of 6 adult male rabbits were clipped free of hair over
the back and trunk area and fitted with plastic collars. The test
material (1000, 1250, 1350, 1500, 2000, or 4000 mg/kg) was
applied to intact skin on each rabbit under one gauze pad. The
trunk of each rabbit was then wrapped with a layer of plastic
wrap, stretch gauze bandage, and elastic adhesive tape. After
a 24-hour exposure period, the wrappings were removed, the
rabbits were wiped with a dry towel, and returned to their
cages. The rabbits were observed and/or weighed daily
(except weekends) over a 14-day recovery period and then
sacrificed.
The LD50 value was calculated from mortality data, using the method of D.J. Finney (Finney, D.J., Probit Analysis, 2nd Ed., 1952 Cambridge University Press. - GLP compliance:
- no
- Remarks:
- GLP not followed
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Adiponitrile
- EC Number:
- 203-896-3
- EC Name:
- Adiponitrile
- Cas Number:
- 111-69-3
- Molecular formula:
- C6H8N2
- IUPAC Name:
- hexanedinitrile
- Details on test material:
- - Name of test material (as cited in study report): Adiponitrile; Hexanedinitriles; Hexanedioic acid dinitrile
- Other: CAS: 111-69-3
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back and trunk area
- Type of wrap if used: plastic wrap, strech gauze bandages and elastic adhesive tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wipres with a dry towel
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1000 mg/kg, 1250 mg/kg, 1350 mg/kg, 1500 mg/kg, 2000 mg/kg, 4000 mg/kg.
- For solids, paste formed: no - Duration of exposure:
- 24 hours
- Doses:
- 1000, 1250, 1350, 1500, 2000, or 4000 mg/kg
- No. of animals per sex per dose:
- 6
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily
- Other examinations performed: clinical signs: Intermittent weight loss at all levels tested. Gasping, diarrhea and lethargy at 4000 mg/kg. All deaths occurred within 2 days after dosing.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 134 mg/kg bw
- Mortality:
- Mortality of 0/6, 0/6, 3/6, 4/6, 3/6, 4/6 was observed in the
1000, 1250, 1350, 1500, 2000, and 4000 mg/kg dose groups,
respectively. Intermittent weight loss occurred at all levels - Clinical signs:
- other: respectively. Intermittent weight loss occurred at all levels tested. Gasping, diarrhea, and lethargy occurred at 4000 mg/kg. All deaths occurred within 2 days after dosing.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information >2000 mg/kg Criteria used for interpretation of results: OECD GHS
- Conclusions:
- 2134 mg/kg dermal LD50 is above classification levels for toxic substances/preparations
- Executive summary:
LD50 - ROUTE: Skin; DOSE: 2134 mg/kg/24H rabbit
Mortality of 0/6, 0/6, 3/6, 4/6, 3/6, 4/6 was observed in the
1000, 1250, 1350, 1500, 2000, and 4000 mg/kg dose groups,
respectively. Intermittent weight loss occurred at all levels
tested. Gasping, diarrhea, and lethargy occurred at
4000 mg/kg. All deaths occurred within 2 days after dosing.
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