Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 904-693-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Overview of aquatic toxicity data for Terpinyl Acetate multi based on data from Terpinyl Acetate alpha, it key constituent
Species |
Method |
Results |
Remarks |
Desmodesmus subspicatus |
Read across from key constituent Terpinyl Acetate alpha. |
72h-EC50 (growth rate): 6.9 72h-EC10 (growth rate): 4.1 |
The source was tested according to OECD TG 201. Results based on geometric mean measured concentrations Key study; Rel. 2 because of read across |
Daphnia magna |
Read across from key constituent Terpinyl Acetate alpha |
48h-EC50: >10
|
The source was tested according to OECD TG 202 using flow through conditions. Key study, Rel. 2 because of read across |
Oncorhynchus mykiss
|
Read across from key constituent Terpinyl Acetate alpha |
96h-LC50: >11 |
The source was tested according to OECD TG 203 using flow through conditions. Key study, Rel. 2 because of read across |
Activated sludge from domestic waste |
Read across from key constituent Terpinyl Acetate alpha |
28d-NOEC: 100 mg/l |
The source results are derived from the ready biodegradability test (OECD TG 301F) in which no effects are anticipated at 100 mg/l because the substance is readily biodegradable. Key study, Rel. 2 because of read across |
Additional information
The information for Terpinyl Acetate multi can be derived from Terpinyl Acetate alpha because the alpha is the main constituent of the multi. The read across justification and documentation is presented below.
Aquatic toxicity of Terpinyl Acetate multi using read across from Terpinyl Acetate alpha (CAS no.80-26-2).
Introduction and hypothesis for the analogue approach
Terpinyl Acetate multi’s constituents have a hydrocarbon backbone to which an acetic ester is attached. For its key constituent aquatic toxicity information is available but not for the others constituents. In accordance with Article 13 of REACH, lacking information can be generated by i.e. applying alternative methods such as in vitro tests, QSARs, grouping and read-across. For assessing the aquatic toxicity of Terpinyl Acetate multi the analogue approach is selected because for the analogue Terpinyl Acetate alpha acute aquatic toxicity information is available which can be used for read across.
Hypothesis: Terpinyl Acetate multi has the same acute aquatic toxicity as Terpinyl Acetate alpha. Conversion is not needed because the log Kow of the constituents are all around 4.4.
Available information: For Terpinyl Acetate alpha acute aquatic toxicity data are available according to OECD TG 201,202 and 203 (Klimisch 1). The lowest value acute toxicity value is the EC50 for algae: 6.9 mg/l. The NOEC/EC10 is 4.3, respectively.
Target chemical and source chemical
Chemical structures of Terpinyl Acetate multi and key constituent Terpinyl Acetate alpha are shown in the data matrix, including physico-chemical properties and other aquatic toxicity values thought relevant for the read across.
Purity / Impurities
Terpinyl Acetate multi is a reaction mass containing a mixture of isomers, which differ on the site where the ester is attached. An overview of the constituents is presented in the data matrix. The impurities are < 10%.
Analogue approach justification
According to Annex XI 1.5 read across can be used to replace testing when the similarity can be based on a common backbone and a common functional group. When using read across the result derived should be applicable for C&L and/or risk assessment and it should be presented with adequate and reliable documentation, which is presented below.
Analogue justification: For Terpinyl Acetate multi its key constituent Terpinyl Acetate alpha is selected because it is the main constituent for which acute toxicity information is available.
Structural similarities and differences: Terpinyl Acetate multi’s key constituent is Terpinyl Acetate alpha and this is the same substance. The read across is to Terpinyl acetate gamma and the impurities cis and trans-beta Terpinyl acetate (the latter having the ester bond at the same spot in the structure as gamma) is based on the similar hydrocarbon backbone and the same acetate ester group. The presence of the double bond in the cyclohexyl ring and absence of this bond in the gamma isomer is discussed in the aquatic reactivity.
Bioavailability: Terpinyl Acetate multi’s constituents, alpha and gamma have similar bioavailability based on the similarity in chemical structure, molecular weight and log Kow values (all close to 4.4).
Aquatic reactivity: Terpinyl Acetate multi constituents all are considered to have the same ester reactivity as presented by ECOSAR and therefore resulting in the same aquatic toxicity values. The double bond in the ring versus outside the ring for the Terpinyl Acetate alpha and gamma, respectively, did not show an impact in ECOSAR. ECOSAR predict a 0.13 higher log Kow (4.467 and 4.337 for gamma and alpha, respectively), which is considered insignificant when assessing the aquatic toxicity.
Uncertainty of the prediction: There are two impurities cis and trans-beta terpinyl acetate making up together ca 10%. These have a log Kow around 4.4 are categorised similarly to the alpha and the gamma isomers and therefore will present the same aquatic toxicity as the alpha and gamma isomers.
Data matrix
The relevant information on physico-chemical properties and other environmental fate properties are presented in the Data Matrix below.
Conclusions for Aquatic toxicity
For Terpinyl Acetate multi as such no aquatic toxicity data are available. For its key constituent Terpinyl Acetate alpha acute aquatic toxicity information is available, which can be used for read across to the other constituents. This is based on structural similarity, Ester categorisation by ECOSAR and log Kow similarity
Final conclusion: Terpinyl Acetate multi-constituents has an LC50 fish, EC50 Daphnia and EC50 algae of > 11, >10 and 6.9 mg/l; it has an EC10/NOEC of 4.1 mg/l
Data matrix to support Aquatic toxicity read across to Terpinyl Acetate multi constituents from Terpinyl Acetate alpha
Common names |
Terpinyl Acetate multi |
Terpinyl Acetate alpha |
Terpinyl Acetate gamma |
|
Target |
Target |
Target |
Chemical structures |
See constituents |
||
Constituent % typical values |
>=84% |
55-75 |
14-26 |
Cas no |
See constituents |
80-26-2 |
10235-63-9 |
EINECS no |
904-693-9 |
201-265-7 |
233-564-3 |
REACH registration |
Yes |
Yes |
No |
Empirical formula |
C12H20O2 |
C12H20O2 |
C12H20O2 |
Molecular weight |
196 |
196 |
196 |
Physico-chemical data |
|
|
|
Physical state |
Liquid |
Liquid |
Likely a liquid |
Log Kow |
4.4 |
4.4 |
Read across from Terpinyl Acetate alpha |
Log Kow EpiSuite |
|
4.337 |
4.467 |
Environmental Fate |
|
|
|
Log Koc |
Read across from Terpinyl Acetate alpha |
2.79 |
|
Biodegradability |
Read across |
Readily |
Read across from Terpinyl Acetate alpha |
Aquatic toxicity |
|
|
|
Acute fish toxicity: LC50 (mg/L) |
Read across from Terpinyl Acetate alpha |
>11 (OECD TG 203) |
Read across from Terpinyl Acetate alpha |
Acute Daphnia: EC50 mg/l |
Read across from Terpinyl Acetate alpha |
>10 (OECD TG 202) |
Read across from Terpinyl Acetate alpha |
Acute Alga: EC50 in mg/l |
Read across from Terpinyl Acetate alpha |
6.9 (OECD TG 201) |
Read across from Terpinyl Acetate alpha |
Long-term Algae EC10/Algae |
Read across from Terpinyl Acetate alpha |
4.1 (OECDTG 201) |
Read across from Terpinyl Acetate alpha |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.