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Diss Factsheets
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EC number: 642-902-2 | CAS number: 163802-53-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.019 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.19 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.002 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 1.7 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.069 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.007 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.003 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
The hydrolysis half-life of 3-(trimethoxysilyl)propyl-(2E,4E)-hexa-2,4-dienoate is 4.7 h at pH 7 and 25°C. It has a measured water solubility of 442 mg/l and log Kow of 3.09. The registration substance will hydrolyse in contact with water and atmospheric moisture to 3-(trihydroxysilyl)propyl-(2E,4E)-2,4-hexadienoate and methanol.
3-(Trihydroxysilyl)propyl-(2E,4E)-2,4-hexadienoate has a high predicted water solubility of 1.0E+06 mg/l, limited to approximately 1000 mg/l by condensation reactions, and a low predicted log Kow of -0.3.
REACH guidance (ECHA 2016, R.16) states that “for substances where hydrolytic DT50 is less than 12 hours, environmental effects are likely to be attributed to the hydrolysis product rather than to the parent itself”. TGD and ECHA guidance, (EC 2003, ECHA 2016) also suggest that when the hydrolysis half-life is less than 12 hours, the breakdown products, rather than the parent substance, should be evaluated for aquatic toxicity. Therefore, the environmental hazard assessment, including sediment and soil compartments due to water and moisture being present, is based on the properties of the silanol hydrolysis product, in accordance with REACH guidance.
As described in Section 4.8, the silanol hydrolysis products may be susceptible to condensation reactions.
Consideration of the non silanol hydrolysis product methanol
Methanol is well characterised in the public domain literature and is not hazardous at the concentrations relevant to the studies; the short-term EC50 and LC50 values for this substance is in excess of 1000 mg/l (OECD 2004 - SIDS for methanol, CAS 67-56-1). Therefore, at the loading rates experienced in these tests it is unlikely that the presence of methanol would significantly affect the results of the tests.
Conclusion on classification
The substance has reliable short-term E(L)C50 values of 19 mg/l in fish, >22 mg/l in invertebrates and >76 mg/l in algae expressed in terms of the hydrolysis product 3-(trihydroxysilyl)propyl-(2E,4E)-2,4-hexadienoate. It has reliable a NOEC of 76 mg/l in algae and reliable a long-term EC10 of 1.9 mg/l in Daphnia, also expressed in terms of the hydrolysis product 3-(trihydroxysilyl)propyl-(2E,4E)-2,4-hexadienoate.
The substance hydrolyses rapidly in water and is not readily biodegradable. The log Kow of the silanol hydrolysis product is -0.3.
The most sensitive species tested was fish. The long-term data do not represent this species, therefore it may be concluded that adequate chronic toxicity data are not available. This would lead to the following classification, using the LC50 value obtained in the short-term fish study of 19 mg/l, under Regulation (EC) No 1272/2008 (as amended) (CLP):
Acute toxicity: Not classified.
Chronic toxicity: Category Chronic 3.
(Under GHS outside the EU, an acute toxicity classification (Category Acute 3) may be applied.)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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